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Adiponectin receptor as a key player in healthy longevity and obesity-related diseases

机译:脂联素受体是健康长寿和肥胖相关疾病的关键因素

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Adiponectin is a fat-derived hormone whose reduction plays central roles in obesity-linked diseases including insulin resistance/type 2 diabetes and atherosclerosis. The cloning of Adiponectin receptors AdipoR1 and AdipoR2 has stimulated adiponectin research, revealing pivotal roles for AdipoRs in pleiotropic adiponectin actions, as well as some postreceptor signaling mechanisms. Adiponectin signaling has thus become one of the major research fields in metabolism and clinical medicine. Studies on AdipoRs will further our understanding of the role of adiponectin in obesity-linked diseases and shortened life span and may guide the design of antidiabetic and antiaging drugs with AdipoR as a target.
机译:脂联素是一种脂肪来源的激素,其减少在与肥胖有关的疾病(包括胰岛素抵抗/ 2型糖尿病和动脉粥样硬化)中起着重要作用。脂联素受体AdipoR1和AdipoR2的克隆刺激了脂联素的研究,揭示了脂联素在多效脂联素作用以及某些受体后信号传导机制中的关键作用。脂联素信号传导因此已经成为代谢和临床医学的主要研究领域之一。对AdipoR的研究将使我们进一步了解脂联素在肥胖相关疾病中的作用并缩短寿命,并可能以AdipoR为靶标指导抗糖尿病和抗衰老药物的设计。

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