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首页> 外文期刊>Cell metabolism >Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
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Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling

机译：脂肪细胞炎症对于健康的脂肪组织扩张和重塑至关重要

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Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a fundamentally negative impact on metabolism, we show that proinflammatory signaling in the adipocyte is in fact required for proper adipose tissue remodeling and expansion. Three mouse models with an adipose tissue-specific reduction in proinflammatory potential were generated that display a reduced capacity for adipogenesis in vivo, while the differentiation potential is unaltered in vitro. Upon high-fat-diet exposure, the expansion of visceral adipose tissue is prominently affected. This is associated with decreased intestinal barrier function, increased hepatic steatosis, and metabolic dysfunction. An impaired local proinflammatory response in the adipocyte leads to increased ectopic lipid accumulation, glucose intolerance, and systemic inflammation. Adipose tissue inflammation is therefore an adaptive response that enables safe storage of excess nutrients and contributes to a visceral depot barrier that effectively filters gut-derived endotoxin.
机译：慢性炎症是肥胖与其病理生理后遗症之间的重要联系。与炎症信号从根本上对代谢产生负面影响的观点相反，我们表明脂肪细胞中的促炎信号实际上是适当的脂肪组织重塑和扩张所必需的。生成了具有脂肪组织特异性降低的促炎潜能的三种小鼠模型，它们在体内的脂肪形成能力降低，而体外的分化潜能却没有改变。高脂饮食暴露后，内脏脂肪组织的扩张受到显着影响。这与肠屏障功能降低，肝脂肪变性增加和代谢功能障碍有关。脂肪细胞中局部促炎反应的减弱导致异位脂质蓄积增加，葡萄糖耐量降低和全身性炎症。因此，脂肪组织炎症是一种适应性反应，能够安全地存储多余的养分，并有助于形成内脏储库屏障，从而有效过滤肠源性内毒素。

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