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The multifaceted metabolic microbiome - Marching toward function

机译：多方面的代谢微生物组-向功能迈进

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At a broad, simplistic level, most of us think of microbes as the "bad guys," and the current worldwide Ebola outbreak does not help this perspective. However, there have been hints of partnerships between humans and microbes for centuries. A number of exciting studies have started to unveil the interplay between mammalian and microbial cells in metabolic health, immunity, gut function, colorectal cancer, and even behavior, to name a few. It is humbling to think that microbial cells outnumber human cells by a factor of ten to one and that each of us carries a hundred times as many microbial as human genes. But make no mistake: microbes are not just along for the ride, they are active participants in both their own and their host's health and an (epi)genetic force to be reckoned with. The microbiome is quite likely one of the main determinants of interindividual variability, and understanding human-mi-crobiome intersections will not only aid in bettering human health globally but also help propel personalized medicine and nutrition forward.
机译：从广义上讲，我们大多数人都将微生物视为“坏蛋”，而当前全球范围内的埃博拉疫情也无济于事。然而，已有数百年的历史表明，人类与微生物之间存在着伙伴关系。许多激动人心的研究已经开始揭示哺乳动物细胞与微生物细胞之间在代谢健康，免疫力，肠道功能，结直肠癌乃至行为等方面的相互作用。令人沮丧的是，微生物细胞的数量要比人类细胞多十比一，而我们每个人所携带的微生物数量是人类基因的一百倍。但是请不要误会：微生物不仅是顺风顺水，而且还是自身和宿主健康以及不可忽视的（表观）遗传力量的积极参与者。微生物组很可能是个体间变异性的主要决定因素之一，了解人与微生物的交汇点不仅将有助于全球范围内改善人类健康，而且还将推动个性化医学和营养的发展。

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