...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP.
【24h】

Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP.

机译：CLOCK对MTP和血浆甘油三酸酯的昼夜调节是由SHP介导的。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We examined the role of clock genes in the diurnal regulation of plasma triglyceride-rich apolipoprotein B-lipoproteins and their biosynthetic chaperone, microsomal triglyceride transfer protein (MTP). Clock(mt/mt) mice showed sustained hypertriglyceridemia and high MTP expression. CLOCK knockdown activated MTP promoter and reduced small heterodimer partner (SHP, NROB2). CLOCK upregulated SHP by binding to its E box. SHP suppressed MTP expression by binding to the HNF4alpha/LRH-1 at the MTP promoter. Cyclic expression of MTP after serum shock was abrogated by siCLOCK and siSHP. Plasma triglyceride and MTP showed reduced diurnal variations in Shp(-/-) mice. Whereas peaks and nadirs in SHP expression were inversely correlated with those of MTP, these changes were reduced in Clock(mt/mt) mice. Expression of Shp abrogated hypertriglyceridemia in Clock(mt/mt) mice. Together, these studies describe a role of Clock/Shp in the diurnal regulation of MTP and plasma triglyceride and indicate that disruptions in circadian regulation might cause hyperlipidemia.
机译：我们检查了时钟基因在血浆中富含甘油三酸酯的载脂蛋白B-脂蛋白及其生物合成伴侣，微粒体甘油三酸酯转移蛋白（MTP）的昼夜调节中的作用。 Clock（mt / mt）小鼠表现出持续的高甘油三酯血症和高MTP表达。 CLOCK组合可激活MTP启动子并减少小异二聚体伴侣（SHP，NROB2）。 CLOCK通过绑定到其E框来上调SHP。 SHP通过在MTP启动子上结合HNF4alpha / LRH-1来抑制MTP表达。 siCLOCK和siSHP消除了血清休克后MTP的循环表达。血浆甘油三酸酯和MTP显示Shp（-/-）小鼠的昼夜变化减少。 SHP表达的峰值和最低点与MTP的峰值和最低点负相关，而Clock（mt / mt）小鼠的这些变化却减少了。 Shp消除了Clock（mt / mt）小鼠的高甘油三酯血症。总之，这些研究描述了Clock / Shp在MTP和血浆甘油三酸酯的昼夜调节中的作用，并表明昼夜节律的破坏可能导致高脂血症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号