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首页> 外文期刊>Cell metabolism >The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth.
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The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth.

机译：果蝇雌激素相关的受体指导代谢开关，支持发育增长。

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摘要

Metabolism must be coordinated with development to provide the appropriate energetic needs for each stage in the life cycle. Little is known, however, about how this temporal control is achieved. Here, we show that the Drosophila ortholog of the estrogen-related receptor (ERR) family of nuclear receptors directs a critical metabolic transition during development. dERR mutants die as larvae with low ATP levels and elevated levels of circulating sugars. The expression of active dERR protein in mid-embryogenesis triggers a coordinate switch in gene expression that drives a metabolic program normally associated with proliferating cells, supporting the dramatic growth that occurs during larval development. This study shows that dERR plays a central role in carbohydrate metabolism, demonstrates that a proliferative metabolic program is used in normal developmental growth, and provides a molecular context to understand the close association between mammalian ERR family members and cancer.
机译：代谢必须与发展相协调，以为生命周期的每个阶段提供适当的能量需求。然而，关于如何实现这种时间控制知之甚少。在这里，我们表明果蝇雌核相关受体（ERR）核受体家族的直向同源物指导发育过程中的关键代谢转变。 dERR突变体死于幼虫，其ATP水平低且循环糖水平升高。活性dERR蛋白在胚胎发生中期的表达触发基因表达的协调转换，从而驱动通常与增殖细胞相关的代谢程序，从而支持幼虫发育期间发生的急剧生长。这项研究表明，dERR在碳水化合物代谢中起着核心作用，表明增生性代谢程序可用于正常发育发育，并提供了分子背景来了解哺乳动物ERR家族成员与癌症之间的紧密联系。

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