...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons
【24h】

Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons

机译：瘦素抑制多巴胺神经元中通过STAT3信号运行的奖励作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The adipose hormone leptin potently influences physical activity. Leptin can decrease locomotion and running, yet the mechanisms involved and the influence of leptin on the rewarding effects of running ("runner's high'') are unknown. Leptin receptor (LepR) signaling involves activation of signal transducer and activator of transcription-3 (STAT3), including in dopamine neurons of the ventral tegmental area (VTA) that are essential for reward-relevant behavior. We found that mice lacking STAT3 in dopamine neurons exhibit greater voluntary running, an effect reversed by viral-mediated STAT3 restoration. STAT3 deletion increased the rewarding effects of running whereas intra-VTA leptin blocked it in a STAT3-dependent manner. Finally, STAT3 loss-of-function reduced mesolimbic dopamine overflow and function. Findings suggest that leptin influences the motivational effects of running via LepR-STAT3 modulation of dopamine tone. Falling leptin is hypothesized to increase stamina and the rewarding effects of running as an adaptive means to enhance the pursuit and procurement of food.
机译：脂肪激素瘦素有效影响身体活动。瘦素可以减少运动和奔跑，但尚不清楚瘦素参与奔跑的奖励机制（“奔跑者的高度”）的机制和影响。瘦素受体（LepR）信号传导涉及信号转导子和转录激活子3的激活（ STAT3），包括在与奖励相关的行为至关重要的腹侧被盖区（VTA）的多巴胺神经元中，我们发现，多巴胺神经元中缺少STAT3的小鼠表现出更大的自发奔跑，这种作用被病毒介导的STAT3恢复所逆转。结果表明，瘦素通过LepR-STAT3调节作用影响跑步的动机，而STAT3功能丧失则减少了中脑边缘多巴胺的溢出和功能。假设瘦素下降会增加耐力，跑步的奖励作用是增强追求的适应性手段和食品采购。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号