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首页> 外文期刊>Cell metabolism >Pdgfr beta(+) Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice
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Pdgfr beta(+) Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice

机译：Pdgfr beta（+）的壁脂肪细胞有助于高脂饮食和长时间暴露于成年小鼠引起的脂肪细胞增生

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The expansion of white adipose tissue (WAT) in obesity involves de novo differentiation of new adipocytes; however, the cellular origin of these cells remains unclear. Here, we utilize Zfp423(GFP) reporter mice to characterize adipose mural (Pdgfr beta(+)) cells with varying levels of the preadipocyte commitment factor Zfp423. We find that adipose tissue contains distinct mural populations, with levels of Zfp423 distinguishing adipogenic from inflammatory-like mural cells. Using our "MuralChaser'' lineage tracking system, we uncover adipose perivascular cells as developmental precursors of adipocytes formed in obesity, with adipogenesis and precursor abundance regulated in a depot-dependent manner. Interestingly, Pdgfr beta(+) cells do not significantly contribute to the initial cold-induced recruitment of beige adipocytes in WAT; it is only after prolonged cold exposure that these cells differentiate into beige adipocytes. These results provide genetic evidence for a mural cell origin of white adipocytes in obesity and suggest that beige adipogenesis may originate from multiple sources.
机译：肥胖中白色脂肪组织（WAT）的扩展涉及新脂肪细胞的从头分化。然而，这些细胞的细胞起源仍不清楚。在这里，我们利用Zfp423（GFP）报告基因小鼠表征脂肪壁（Pdgfr beta（+））细胞具有不同水平的前脂肪细胞结合因子Zfp423。我们发现脂肪组织包含不同的壁画种群，Zfp423的水平将脂肪形成性与炎性壁画细胞区分开。使用我们的“ MuralChaser”谱系追踪系统，我们发现脂肪周围血管细胞是肥胖形成的脂肪细胞的发育前体，其脂肪形成和前体丰度以贮库依赖性的方式进行调节，有趣的是，Pdgfr beta（+）细胞不会显着地促进WAT中最初由冷诱导的米色脂肪细胞的募集;只有长时间的冷暴露后，这些细胞才能分化为米色脂肪细胞，这些结果为肥胖中白色脂肪细胞的壁细胞起源提供了遗传学证据，并表明米色脂肪形成可能起源于肥胖多种来源。

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