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首页> 外文期刊>Nanomedicine: Nanotechnology, Biology and Medicine >Controlled loading and release of a model drug from polypeptide multilayer nanofilms
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Controlled loading and release of a model drug from polypeptide multilayer nanofilms

机译：多肽多层纳米膜的模型药物的控制加载和释放

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A major concern of medicine today is the sustained release of therapeutic compounds.Delivery vehicles for such compounds must be biocompatible.Ideally,loading a drug into the delivery vehicle will be a simple process,and vehicle properties will allow control over the drug release profile under desired conditions.Here,polypeptide multilayer nanofilms have been prepared by electrostatic layer-by-layer self-assembly to study the post-fabrication loading and release of a model therapeutic,methylene blue(MB).Drug loading and release have been characterized by optical spectroscopy for different peptide designs at different pH values,and film surface morphology has been characterized by atomic force microscopy(AFM).Differences in peptide structure have been found to influence MB loading and release under otherwise fixed conditions.Release is also influenced by pH,salt concentration,and number of "capping" layers.Although more research will be needed to exhaust the potential of polypeptide multilayer films,present results would suggest that the technology holds considerable promise for applications in medicine.
机译：当今医学的主要关注点是治疗性化合物的持续释放。这类化合物的递送载体必须具有生物相容性。理想情况下，将药物装载到递送载体中将是一个简单的过程，并且载体性质将允许在以下条件下控制药物释放曲线在此，通过静电逐层自组装制备多肽多层纳米膜，以研究模型治疗剂亚甲基蓝（MB）的制备后负载和释放。原子力显微镜（AFM）表征了不同肽设计在不同pH值下的光谱，膜的表面形态已被表征。在不同的固定条件下，肽结构的差异会影响MB的负载和释放.pH也会影响释放，盐浓度和“封盖”层的数量。尽管需要更多的研究以耗尽多肽多聚体的潜力目前的结果表明该技术在医学上具有广阔的应用前景。

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