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Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.

机译:局部刚度分布的剧烈变化与活细胞中的细胞迁移有关。

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摘要

Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed. Copyright 2001 Wiley-Liss, Inc.
机译:在培养条件下,使用扫描探针显微镜在力调制模式下捕获了活纤维细胞(NIH3T3)的局部刚度分布的顺序图像。我们发现细胞迁移与细胞上的局部刚度分布之间存在明确的关系:当细胞固定在一个位置时,其细胞表面的刚度分布非常稳定。另一方面,一旦细胞开始运动,其核区域的刚度就会急剧下降。提出了可能的解释细胞迁移和细胞刚度之间的相关性。版权所有2001 Wiley-Liss,Inc.

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