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首页> 外文期刊>Cell motility and the cytoskeleton >Growth cones contain myosin II bipolar filament arrays.
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Growth cones contain myosin II bipolar filament arrays.

机译：生长锥包含肌球蛋白II双极细丝阵列。

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摘要

Nonmuscle myosin II is among the most abundant forms of myosin in nerve growth cones. At least two isoforms of myosin II (A and B) that have overlapping but distinct distributions are found in growth cones. It appears that both myosin IIA and IIB may be necessary for normal nerve outgrowth and motility, but the molecular interactions responsible for their activity remain unclear. For instance, it is unknown if these myosin II isoforms produce bipolar "minifilaments" in growth cones similar to those observed in other nonmuscle cells. To determine if minifilaments are present in growth cones, we modified the electron microscopy preparative procedures used to detect minifilaments in other cell types. We found structures that appeared very similar to bipolar minifilaments found in noneuronal cells. They also labeled with antibodies to either myosin IIA or IIB. Thus, the activity of myosin II in growth cones is likely to be similar to that in other nonmuscle cells. Bipolar filaments interacting with oppositely oriented actin filaments will produce localized contractions or exert tension on actin networks. This activity will be responsible for the myosin II dependent motility in growth cones. Cell Motil. Cytoskeleton 52:91-96, 2002.
机译：非肌肉肌球蛋白II是神经生长锥中最丰富的肌球蛋白形式之一。在生长锥中发现了至少两种具有重叠但不同分布的肌球蛋白II（A和B）同工型。似乎肌球蛋白IIA和IIB可能对于正常的神经生长和运动都是必需的，但是负责其活性的分子相互作用仍然不清楚。例如，未知这些肌球蛋白II同工型是否在生长锥中产生类似于在其他非肌肉细胞中观察到的双极“微丝”。为了确定生长锥中是否存在细丝，我们修改了用于检测其他细胞类型细丝的电子显微镜制备程序。我们发现的结构看起来与非神经元细胞中的双极微丝非常相似。它们还用肌球蛋白IIA或IIB抗体标记。因此，肌球蛋白II在生长锥中的活性可能与其他非肌肉细胞中的相似。与极性相反的肌动蛋白丝相互作用的双极丝将产生局部收缩或在肌动蛋白网络上施加张力。这项活动将负责生长锥中肌球蛋白II依赖的运动。细胞动力。 Cytoskeleton 52：91-96，2002。

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