AFM imaging of protein movements: histone H2A-H2B release during nucleosome remodeling.

Bash R; Wang H; Anderson C; Yodh J; Hager G; Lindsay SM; Lohr D

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AFM imaging of protein movements: histone H2A-H2B release during nucleosome remodeling.

机译：蛋白质运动的AFM成像：核小体重塑过程中组蛋白H2A-H2B释放。

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Being able to follow assembly/disassembly reactions of biomolecular complexes directly at the single molecule level would be very useful. Here, we use an AFM technique that can simultaneously obtain topographic images and identify the locations of a specific type of protein within those images to monitor the histone H2A component of nucleosomes acted on by human Swi-Snf, an ATP-dependent nucleosome remodeling complex. Activation of remodeling results in significant H2A release from nucleosomes, based on recognition imaging and nucleosome height changes, and changes in the recognition patterns of H2A associated directly with hSwi-Snf complexes.

机译：能够直接在单分子水平上追踪生物分子复合物的组装/拆卸反应将是非常有用的。在这里，我们使用一种AFM技术，该技术可以同时获取地形图并在这些图像中识别特定类型蛋白质的位置，以监控人类Swi-Snf（一种依赖ATP的核小体重塑复合体）作用的核小体的组蛋白H2A组分。基于识别成像和核小体高度变化，以及与hSwi-Snf复合体直接相关的H2A识别模式的改变，重塑的激活导致H2A从核小体中大量释放。

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《FEBS letters.》 |2006年第19期|共5页
作者
Bash R; Wang H; Anderson C; Yodh J; Hager G; Lindsay SM; Lohr D;
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正文语种 eng
中图分类生物化学;
关键词
Nucleosomes; Discharge (release); Microscopy; Atomic Force; Proteins; Histones; 核小体; 显微镜检查; 原子力; 蛋白质类; 组蛋白类;

机译：Nucleosomes;Discharge (release);Microscopy;Atomic Force;Proteins;Histones;核小体;显微镜检查;原子力;蛋白质类;组蛋白类;

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1. AFM imaging of protein movements: histone H2A-H2B release during nucleosome remodeling. [J] . Bash R, Wang H, Anderson C, FEBS letters. . 2006,第19期

机译：蛋白质运动的AFM成像：核小体重塑过程中组蛋白H2A-H2B释放。
2. Histone Release during Transcription:Acetylation Stabilizes the Interaction of the H2A-H2B Dimer with the H3-H4 Tetramer in Nucleosomes That Are on Highly Positively Coiled DNA [J] . Ann Wunsch, Vaughn Jackson Biochemistry . 2005,第49期

机译：转录过程中的组蛋白释放：乙酰化作用可稳定H2A-H2B二聚体与H3-H4四聚体在高度阳性螺旋DNA上的核小体中的相互作用。
3. Comparison of non histone proteins selectively associated with nucleosomes with proteins released during limited DNase digestions [J] . C. Terrioux, F. Gros, J. Kruh, Nucleic acids research . 1979,第3期

机译：选择性限制核糖核酸酶消化过程中释放的蛋白质与非组蛋白与核小体选择性结合的比较
4. Analysis of the Histone Protein Tail and DNA in Nucleosome Using Molecular Dynamics Simulation [C] . R. Fujimori, Y. Komatsu, M. Fukuda, International Symposium on Slow Dynamics in Complex Systems . 2013

机译：用分子动力学模拟分析核小体中的组蛋白蛋白尾和DNA
5. Modification of histone H4 promotes centromere protein-A nucleosome assembly: Molecular mechanisms of centromeric chromatin assembly. [D] . Godek, Kristina M. 2010

机译：组蛋白H4的修饰促进着丝粒蛋白A核小体装配：着丝粒染色质装配的分子机制。
6. Comparison of non histone proteins selectively associated with nucleosomes with proteins released during limited DNase digestions. [O] . N Defer, M Crepin, C Terrioux, 1979

机译：比较与核小体选择性结合的非组蛋白与在有限的DNase消化过程中释放的蛋白质的比较。
7. AFM imaging of protein movements: Histone H2A–H2B release during nucleosome remodeling [O] . Bash R., Wang H., Anderson C., 2006

机译：AFM成像的蛋白质运动：核小体重塑过程中组蛋白H2A–H2B释放

AFM imaging of protein movements: histone H2A-H2B release during nucleosome remodeling.

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