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首页> 外文期刊>Cell motility and the cytoskeleton >A healthy understanding of intraflagellar transport.
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A healthy understanding of intraflagellar transport.

机译：对鞭毛内运输的健康理解。

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A microtubule-dependent motility process called intraflagellar transport (IFT) occurs beneath the plasma membrane of cilia and flagella. IFT was first observed in Chlamydomonas, and orthologs of some of the polypeptides involved in IFT have recently been identified in other organisms, including C. elegans and the mouse. In addition to a role in the assembly and maintenance of cilia and flagella, evidence is reviewed here that indicates defects in the process of IFT may be related to problems with human health. Moreover, recent data suggest the possibility of two new roles for IFT in cell function. The first is in transcriptional control of the genes encoding ciliary and flagellar proteins. IFT could provide a mechanism whereby the cell senses the presence or absence of its cilia or flagella and responds by turning on gene transcription resulting in replacement of the missing organelle. The second role is in signal transduction, whereby cilia act as sensors of the external cellular environment and transduce information about the surroundings into intracellular signals that are sent via IFT to the cell body, thus inducing an appropriate cellular response to the environment. Cell Motil. Cytoskeleton 52:1-8, 2002.
机译：纤毛和鞭毛的质膜下方会发生称为鞭毛内运输（IFT）的依赖微管的运动过程。 IFT首先在衣藻中观察到，最近在其他生物中发现了参与IFT的某些多肽的直系同源物，包括秀丽隐杆线虫和小鼠。除了在纤毛和鞭毛的组装和维护中发挥作用外，这里还回顾了证据表明，IFT过程中的缺陷可能与人类健康问题有关。此外，最近的数据表明IFT在细胞功能中可能有两个新作用。首先是对编码睫毛和鞭毛蛋白的基因进行转录控制。 IFT可以提供一种机制，使细胞能够感知其纤毛或鞭毛的存在与否，并通过打开基因转录进行响应，从而导致缺失的细胞器被替换。第二个作用是信号传导，纤毛充当外部细胞环境的传感器，并将周围环境的信息转化为通过IFT发送到细胞体的细胞内信号，从而引起对环境的适当细胞反应。细胞动力。 Cytoskeleton 52：1-8，2002。

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