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首页> 外文期刊>Laboratory Animal Science >PROLIFERATIVE LESIONS OF THE TESTIS IN AD LIBITUM-FED AND FOOD-RESTRICTED FISCHER-344 AND FBNF1 RATS
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PROLIFERATIVE LESIONS OF THE TESTIS IN AD LIBITUM-FED AND FOOD-RESTRICTED FISCHER-344 AND FBNF1 RATS

机译：食用脂肪限制的FISCHER-344和FBNF1大鼠的睾丸增生性病变

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The effect of 40% food restriction on spontaneous proliferative lesions of the testis was evaluated in lifetime and cross-sectional (serial sacrifice) studies of 419 Fischer (F-344) and 304 Fischer x Brown Norway (FBNF1) male rats. Interstitial cell hyperplasia and interstitial cell adenoma (ICA) were the most common proliferative lesions in each genotype; incidence of each was less in the FBNF1. In each genotype, food restriction delayed the onset of both lesions and reduced the incidence of ICA. At 12 months interstitial cell hyperplasia was present in 11 of 12 ad libitum (AL) fed and 0 of 12 food-restricted (FR) F-344 rats. In FBNF1 rats interstitial cell hyperplasia was observed first at 18 months in AL-fed and at 36 months in FR groups. Interstitial cell adenoma developed in 5 of 12 AL-fed F-344 rats by 18 months and in 2 of 12 FR rats by 24 months; 2 of 12 AL-fed FBNF1 rats had ICA at 30 months, and 1 of 12 FR rats had ICA at 42 months. In these cross-sectional studies approximately half the ICA cases in F-344 rats were bilateral; no FBNF1 rats had bilateral ICA. In lifetime studies the incidence of ICA was reduced from 49% in AL-fed rats to 19% in FR F-344 rats and from 9% in AL to 4% in FR FBNF1 rats. The incidence of mesothelioma was low in both genotypes and was not obviously altered by food restriction. A malignant embryonal neoplasm, an unclassified benign neoplasm, and three seminomas were present in the testes of FBNF1 rats.
机译：在419只Fischer（F-344）和304只Fischer x Brown Norway（FBNF1）雄性大鼠的寿命和横断面（串行牺牲）研究中，评估了40％食物限制对睾丸自发性增生性病变的影响。间质细胞增生和间质细胞腺瘤（ICA）是每种基因型中最常见的增殖性病变。 FBNF1中每一种的发生率均较低。在每种基因型中，食物限制会延迟两种病变的发作并降低ICA的发生率。在12个月时，在12只随意喂养（AL）的11只和12只食物受限（FR）的F-344大鼠中有0只存在间质细胞增生。在FBNF1大鼠中，首先在AL喂养的18个月和FR组的36个月观察到间质细胞增生。间质细胞腺瘤在18个月前的12只由AL喂养的F-344大鼠中有5只在24个月后的12只在FR大鼠中有2只出现。 12只AL喂养的FBNF1大鼠中有2只在30个月时有ICA，而12只FR大鼠中的1只在42个月时有ICA。在这些横断面研究中，F-344大鼠中大约一半的ICA病例是双侧的。没有FBNF1大鼠有双侧ICA。在终生研究中，ICA的发生率从用AL喂养的大鼠中的49％降低到FR F-344大鼠中的19％，并且从AL中的9％降低到FR FBNF1大鼠中的4％。两种基因型间皮瘤的发生率均较低，并且受食物限制并未明显改变。 FBNF1大鼠的睾丸中有恶性胚胎肿瘤，未分类的良性肿瘤和三个精原细胞瘤。

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