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首页> 外文期刊>Laboratory Animal Science >HUMANE AND PRACTICAL IMPLICATIONS OF USING CARBON DIOXIDE MIXED WITH OXYGEN FOR ANESTHESIA OR EUTHANASIA OF RATS
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HUMANE AND PRACTICAL IMPLICATIONS OF USING CARBON DIOXIDE MIXED WITH OXYGEN FOR ANESTHESIA OR EUTHANASIA OF RATS

机译：二氧化碳与氧气混合使用对大鼠麻醉或感觉异常的人为和现实意义

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A series of studies was undertaken to determine whether CO2, can be used as a humane as well as practical agent for euthanasia or anesthesia of rats. Human volunteers rated the degree of discomfort associated with breathing 50 to 100% CO2, mixed with oxygen. Increasing concentrations of CO2 were judged as progressively more noxious, from ''highly unpleasant'' for 50% CO2, to ''painful'' for 100% CO2. The practical aspects of anesthesia and euthanasia with 50 to 100% CO2, were studied, using male Sprague Dawley rats. Time to anesthesia and death were inversely related to CO2, concentration, as were the frequency and severity of adverse reactions, including seizures and hemorrhaging from the nose. The severity of edema and hemorrhage, which were observed on histologic examination of the lungs of all rats euthanized with CO2, were greatest in the animals exposed to the lowest concentrations. There were no significant. effects of CO2, concentration on time to recumbency or recovery, and there were no significant effects of precharging versus not precharging the chamber on any of the parameters studied. It was concluded that, although CO2, can be used in a humane manner, the concentrations that are least likely to cause pain and distress are associated with the longest times to anesthesia and death, highest incidence of unwanted side effects, and most severe histologic changes in the lungs. Acceptably humane and reasonably practical euthanasia or anesthesia can be achieved using a nonprecharged chamber and a low gas flow rate so that conscious animals are never exposed to CO2 concentrations >70%.
机译：进行了一系列研究来确定CO2是否可以用作安乐死或大鼠麻醉的人道和实用剂。人类志愿者对与氧气混合50至100％的CO2呼吸相关的不适程度进行了评估。二氧化碳浓度的增加被认为是有害的，从“非常不愉快”的50％CO2变为“痛苦的” 100％CO2。使用雄性Sprague Dawley大鼠研究了麻醉和50至100％CO2的安乐死的实际情况。麻醉和死亡时间与二氧化碳，浓度以及不良反应的发生频率和严重程度（包括癫痫发作和鼻子出血）成反比。在用最低浓度的动物中，对所有用CO 2安乐死的大鼠的肺进行组织学检查时观察到的水肿和出血的严重程度最大。没有重大意义。二氧化碳，浓度对卧倒或恢复时间的影响，并且在任何研究的参数上，预充与不预充室均无显着影响。结论是，尽管可以以人性化的方式使用CO2，但最不可能引起疼痛和痛苦的浓度与最长的麻醉和死亡时间，最高的不良副作用发生率以及最严重的组织学改变有关在肺里。使用不带预充压力的腔室和低气体流速可以实现可接受的人道化和合理可行的安乐死或麻醉，从而使有意识的动物永远不会暴露于> 70％的CO2浓度。

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