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首页> 外文期刊>Laboratory Animal Science >EFFECT OF SUBLETHAL IRRADIATION OF SCID MICE ON GROWTH OF B-CELL LYMPHOMA XENOGRAFTS AND ON EFFICACY OF CHEMOTHERAPY AND/OR IMMUNOTOXIN THERAPY
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EFFECT OF SUBLETHAL IRRADIATION OF SCID MICE ON GROWTH OF B-CELL LYMPHOMA XENOGRAFTS AND ON EFFICACY OF CHEMOTHERAPY AND/OR IMMUNOTOXIN THERAPY

机译：辐射对小鼠的致命影响对B细胞淋巴瘤异种移植物的生长以及对化学疗法和/或免疫毒素疗法的功效

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Severe combined immune deficiency (SCID) mice obtained from different vendors vary in their capacity to accept human tumor xenografts, and in some instances mice must first be irradiated, It has been reported that SCID mice are particularly sensitive to irradiation which, in addition, can partially restore their immune system so that they are no longer totally immunologically incompetent, For the past several years we have used nonirradiated SCID mice to grow human B-cell lymphomas, When we changed vendors, we found it necessary to irradiate the mice before xenografting. Sublethal irradiation of at least one source of SCID mice before tumor cell inoculation improved tumor take and dissemination, but irradiation changed the response of these mice to chemotherapy and immunotoxins. Thus the irradiated mice did not respond to chemotherapy, but the two immunotoxins used for therapy became more effective in extending survival of the mice. It then appears that irradiation affects the immune system of SCID mice in such a way as to change their response to the therapeutic regimens used here.
机译：从不同供应商处获得的严重联合免疫缺陷（SCID）小鼠接受人类肿瘤异种移植物的能力各不相同，在某些情况下必须首先对小鼠进行辐照。据报道，SCID小鼠对辐照特别敏感，此外，它还能部分恢复其免疫系统，使它们不再完全失去免疫学功能。在过去的几年中，我们使用了未经辐照的SCID小鼠来培养人B细胞淋巴瘤。当我们更换供应商时，我们发现有必要在异种移植之前对小鼠进行辐照。在肿瘤细胞接种之前，对至少一种来源的SCID小鼠进行亚致死性辐照可以改善肿瘤的发生和扩散，但是辐照改变了这些小鼠对化学疗法和免疫毒素的反应。因此，受辐照的小鼠对化疗没有反应，但是用于治疗的两种免疫毒素在延长小鼠的存活率方面变得更加有效。然后看来，辐射以改变它们对此处使用的治疗方案的反应的方式影响SCID小鼠的免疫系统。

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