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首页> 外文期刊>Laboratory Animal Science >EVALUATION OF CECAL LIGATION AS A MODEL OF MUCOID ENTEROPATHY IN SPECIFIC-PATHOGEN-FREE RABBITS
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EVALUATION OF CECAL LIGATION AS A MODEL OF MUCOID ENTEROPATHY IN SPECIFIC-PATHOGEN-FREE RABBITS

机译：盲肠结扎作为无特定病原性家兔粘液性肠病模型的评估

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摘要

Mucoid enteropathy is a serious disease of rabbits, the cause of which is unknown, Ligation of the cecum has been reported to cause a mucoid enteropathy-like syndrome in 70% of conventional rabbits, The goal of this study was to evaluate this model of mucoid enteropathy in Pasteurella-free, coccidia-free rabbits for use in future studies, Five rabbits served as unoperated controls (group 1), Eight rabbits underwent ligation of the cecum, with large vessels and nerves spared (group 2), In six rabbits the distal branch of the ileocecocolic vessels and nerve were incorporated into the cecal ligature (group 3), At necropsy 3 to 5 days after surgery, all group-3 rabbits had copious amounts of clear, gelatinous mucus in the colon, Only one group-a rabbit had grossly evident mucus hypersecretion, whereas none of the group-1 rabbits did, Group-3 rabbits had areas of necrosis in the cecum; this was not seen in group-1 or group-2 rabbits, Rabbits of groups 2 and 3 had inflammation of the distal portion of the colon, In specific-pathogen-free rabbits cecal ligation alone did not reliably stimulate mucus hypersecretion but induced a disease similar 60 natural mucoid enteropathy, Cecal ligation including vessels provided a reproducible syndrome of mucus hypersecretion; however, the severe cecal necrosis was not consistent with the naturally acquired disease.
机译：粘液样肠病是一种严重的兔子疾病，其病因尚不清楚，据报道盲肠结扎可引起70％的常规兔类粘液样肠病样综合征，本研究的目的是评估这种粘液样模型在无巴斯德氏菌，无球虫的兔子中进行肠病治疗，以备将来研究;五只兔子作为未手术的对照组（第1组）;八只兔子进行盲肠结扎，大血管和神经被保留（第2组）;六只兔子将盲肠球菌血管和神经的远端分支合并到盲肠结扎物中（第3组），在尸检后3至5天进行剖检，所有第3组的兔子在结肠中都有大量透明的凝胶状粘液，只有一组-a兔具有明显明显的粘液分泌过多，而第1组的兔子则没有，第3组的兔子在盲肠中有坏死区域。在第1组或第2组的兔子中未见到这种情况;第2和3组的兔子患有结肠远端的炎症。在无特定病原体的兔子中，盲肠结扎仅不能可靠地刺激粘液分泌过多，但会诱发疾病类似的60种天然粘液性肠病，包括血管的盲肠结扎提供了可复制的粘液分泌过多综合征;然而，严重的盲肠坏死与自然获得性疾病不一致。

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