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首页> 外文期刊>Laboratory Animal Science >Evaluation of hyperplastic goiter in a colony of Syrian hamsters (Mesocricetus auratus).
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Evaluation of hyperplastic goiter in a colony of Syrian hamsters (Mesocricetus auratus).

机译：叙利亚仓鼠（Mesocricetus auratus）群落中增生性甲状腺肿的评估。

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Hyperplastic goitre occurred among juveniles and adults in a Syrian hamster colony (SG) at a prevalence of 45%. Enlarged thyroid glands had significant follicular cell hyperplasia. Juvenile male SG hamsters were compared with age- and sex-matched Syrian hamsters from an unrelated colony which did not have an increased prevalence of goitre (Fredrick Cancer Research and Development Center, USA, FCRDC). Thyroid glands of hamsters were evaluated by 123I radionuclide imaging. Eight of 18 SG hamsters andnone of the FCRDC hamsters had enlarged thyroid glands. Serum baseline and post-thyrotropin thyroxine concentrations in SG hamsters were not statistically different from those in FCRDC hamsters. To investigate the effect of diet on the development of hyperplastic goitre, 15 FCRDC hamsters were fed the diet that had been fed to SG hamsters (mouse breeder diet) and 5 were fed a control diet for 6 months. To determine whether dietary change would result in resolution of goitre, affected SG hamsters were fed a control diet for 3 months. At the end of each feeding trial, thyroid gland uptake of 123I was re-evaluated. The amount of 123I taken up by the thyroid glands of FCRDC hamsters fed the mouse breeder diet was not significantly different from that of controls. In contrast, thyroid gland uptake of 123I remained high for all affected SG hamsters fed the control diet. A diagnosis of euthyroid hyperplastic goitre was made for the SG hamsters. It is suggested that there was a genetic influence on the increased prevalence of goitre in SG hamsters.
机译：叙利亚仓鼠殖民地（SG）的青少年和成年人中发生增生性甲状腺肿，患病率为45％。甲状腺肿大有明显的滤泡细胞增生。将青少年雄性SG仓鼠与年龄和性别相匹配的叙利亚无关的仓鼠进行了比较，该仓鼠的甲状腺肿患病率没有增加（美国弗雷德里克癌症研究与发展中心，FCRDC）。通过123 I放射性核素成像评估仓鼠的甲状腺。 18只SG仓鼠中有8只FCRDC仓鼠中没有一个甲状腺肿大。 SG仓鼠的血清基线和促甲状腺激素后甲状腺素浓度与FCRDC仓鼠的统计学差异无统计学意义。为了研究饮食对增生性甲状腺肿发展的影响，将15只FCRDC仓鼠喂给了SG仓鼠喂食（小鼠饲养员饮食），将5只对照饮食喂了6个月。为了确定饮食变化是否会导致甲状腺肿消退，对受影响的SG仓鼠喂食了3个月的对照饮食。在每次喂养试验结束时，均重新评估了123I对甲状腺的摄取。饲喂小鼠饲养员饮食的FCRDC仓鼠的甲状腺摄取的123I量与对照组无显着差异。相比之下，饲喂对照饮食的所有受影响的SG仓鼠的甲状腺摄取123I仍然很高。诊断为甲亢仓鼠甲状腺功能亢进性甲状腺肿。提示对SG仓鼠甲状腺肿患病率增加有遗传影响。

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