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首页> 外文期刊>NMR in biomedicine >MRS water resonance frequency in childhood brain tumours: a novel potential biomarker of temperature and tumour environment
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MRS water resonance frequency in childhood brain tumours: a novel potential biomarker of temperature and tumour environment

机译：儿童脑肿瘤中的MRS水共振频率：温度和肿瘤环境的新型潜在生物标志物

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~1H MRS thermometry has been investigated for brain trauma and hypothermia monitoring applications but has not been explored in brain tumours. The proton resonance frequency (PRF) of water is dependent on temperature but is also influenced by microenvironment factors, such as fast proton exchange with macromolecules, ionic concentration and magnetic susceptibility. ~1H MRS has been utilized for brain tumour diagnostic and prognostic purposes in children; however, the water PRF measure may provide complementary information to further improve characterization. Water PRF values were investigated from a repository of MRS data acquired from childhood brain tumours and children with apparently normal brains. The cohort consisted of histologically proven glioma (22), medulloblastoma (19) and control groups (28, MRS in both the basal ganglia and parietal white matter regions). All data were acquired at 1.5 T using a short T_E (30 ms) single voxel spectroscopy (PRESS) protocol. Water PRF values were calculated using methyl creatine and total choline. Spectral peak amplitude weighted averaging was used to improve the accuracy of the measurements. Mean PRF values were significantly larger for medulloblastoma compared with glioma, with a difference in the means of 0.0147ppm (p<0.05), while the mean PRF for glioma was significantly lower than for the healthy cohort, with a difference in the means of 0.0061ppm (p<0.05). This would suggest the apparent temperature of the glioma group was ~1.5 °C higher than the medulloblastomas and ~0.7 °C higher than a healthy brain. However, the PRF shift may not reflect a change in temperature, given that alterations in protein content, microstructure and ionic concentration contribute to PRF shifts. Measurement of these effects could also be used as a supplementary biomarker, and further investigation is required. This study has shown that the water PRF value has the potential to be used for characterizing childhood brain tumours, which has not been reported previously.
机译：已经对〜1H MRS体温计进行了脑外伤和体温监测应用的研究，但尚未在脑肿瘤中进行探索。水的质子共振频率（PRF）取决于温度，但也受微环境因素的影响，例如与大分子的快速质子交换，离子浓度和磁化率。 〜1H MRS已用于儿童脑肿瘤的诊断和预后。但是，水PRF度量可能会提供补充信息，以进一步改善特征。水的PRF值是从MRS数据库中调查的，该数据是从儿童脑瘤和脑正常儿童获得的。该队列包括经组织学证实的神经胶质瘤（22），髓母细胞瘤（19）和对照组（28，基底神经节和顶叶白质区域的MRS）。使用短T_E（30 ms）单体素光谱（PRESS）协议在1.5 T下获取所有数据。使用甲基肌酸和总胆碱计算水的PRF值。频谱峰值幅度加权平均被用来提高测量的准确性。与神经胶质瘤相比，髓母细胞瘤的平均PRF值显着更大，均值差异为0.0147ppm（p <0.05），而神经胶质瘤的平均PRF值显着低于健康人群，均值差异为0.0061。 ppm（p <0.05）。这表明神经胶质瘤组的表观温度比成髓细胞瘤高约1.5°C，比健康大脑高约0.7°C。但是，考虑到蛋白质含量，微结构和离子浓度的变化会导致PRF位移，PRF位移可能无法反映温度的变化。这些效果的测量也可以用作补充生物标志物，需要进一步的研究。这项研究表明，水的PRF值有潜力用于表征儿童的脑肿瘤，这一点以前没有报道。

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