Increased percentages of T cells producing interleukin-21 in patients with immune thrombocytopenic purpura.

Qian Zhang; Hai Bai; Wenhui Wang

首页> 外文期刊>Cell biology international. >Increased percentages of T cells producing interleukin-21 in patients with immune thrombocytopenic purpura.

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Increased percentages of T cells producing interleukin-21 in patients with immune thrombocytopenic purpura.

机译：免疫性血小板减少性紫癜患者中产生白介素21的T细胞百分比增加。

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Interleukin (IL)-21, a cytokine which promotes differentiation of Th17, follicular helper T cell and B cells, may play an important role in controlling the autoimmune process in immune thrombocytopenic purpura (ITP), an acquired organ-specific autoimmune hemorrhagic disease. The frequencies of IL-21-producing T cells and serum levels of IL-21 were determined by flow cytometry analysis and ELISA, respectively, in 24 ITP patients and nine healthy controls. RT-PCR showed that the frequencies of circulating IL-21-producing T cells and serum levels of IL-21 were significantly higher in ITP patients than that in healthy controls. Serum IL-21 and IL-21 expression in patients with ITP significantly decreased after therapy, suggesting IL-21 might be important in ITP.

机译：白细胞介素（IL）-21是一种促进Th17，卵泡辅助性T细胞和B细胞分化的细胞因子，在控制免疫性血小板减少性紫癜（ITP）（一种获得性器官特异性自身免疫性出血性疾病）的自身免疫过程中可能发挥重要作用。通过流式细胞术分析和ELISA分别在24名ITP患者和9名健康对照者中确定产生IL-21的T细胞的频率和血清IL-21的水平。 RT-PCR显示ITP患者中循环产生IL-21的T细胞的频率和血清IL-21水平显着高于健康对照组。治疗后ITP患者的血清IL-21和IL-21表达明显降低，提示IL-21在ITP中可能很重要。

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《Cell biology international.》 |2014年第4期|共6页
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Qian Zhang; Hai Bai; Wenhui Wang;
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1. Increased percentages of T cells producing interleukin-21 in patients with immune thrombocytopenic purpura. [J] . Qian Zhang, Hai Bai, Wenhui Wang Cell biology international. . 2014,第4期

机译：免疫性血小板减少性紫癜患者中产生白介素21的T细胞百分比增加。
2. Platelet apoptosis resistance and increased CXCR4 expression in pediatric patients with chronic immune thrombocytopenic purpura. [J] . Wang JD, Ou TT, Wang CJ, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2010,第4期

机译：小儿慢性免疫性血小板减少性紫癜患者的血小板凋亡抗性和CXCR4表达增加。
3. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. [J] . Yu J, Heck S, Patel V, Blood: The Journal of the American Society of Hematology . 2008,第4期

机译：慢性免疫性血小板减少性紫癜患者的循环CD25调节性T细胞缺陷。
4. Platelet count control in immune thrombocytopenic purpura patient: optimum romiplostim dose profile [C] . Chia-Hung Tsai, James Bussel, Allison Imahiyerobo, IFAC World Congress . 2014

机译：免疫血小板减少紫癜患者血小板计数控制：最佳的romiplosim剂量曲线
5. HeLa cell lines producing infectious replication-defective HIV virions with varyinggp160 densities indicate that increasing cellulargp160 levels cause an increase in cell-to-cell fusion, while increasing viralgp160 levels exert a biphasic effect on infectivity. [D] . Berg, Werner Mente. 1999

机译：产生具有变化的gp160密度的感染性复制缺陷型HIV病毒粒子的HeLa细胞系表明，增加的cellgp160水平会引起细胞间融合的增加，而增加的viralgp160水平则会对感染力产生双相效应。
6. Increased circulating Ia-positive T cells in patients with idiopathic thrombocytopenic purpura. [O] . H Mizutani, T Tsubakio, Y Tomiyama, 1987

机译：特发性血小板减少性紫癜患者体内循环Ia阳性T细胞增加。
7. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody. [O] . Kuwana, M, Kaburaki, J, Ikeda, Y 1998

机译：免疫性血小板减少性紫癜中血小板GPIIb-IIIa的自身反应性T细胞。在生产抗血小板自身抗体中的作用。

Increased percentages of T cells producing interleukin-21 in patients with immune thrombocytopenic purpura.

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