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首页> 外文期刊>Cell biology international. >Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients.
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Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients.

机译：CDC25A和细胞周期蛋白E表达对原发性乳腺癌患者的预后意义。

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摘要

Defect in cell cycle control is a hallmark character of cancer. We have investigated the association of Ki67 labeling index, cyclin E and CDC25A expressions with clinical follow-up data in breast carcinomas. Flow cytometry was used to detect gene amplification of cyclins in 44 tumor tissue with invasive breast carcinomas. Multivariate Cox proportional hazard ratio test was used to show the correlations. Cyclin E or CDC25A were upregulated in 34% of the tumors. Among the whole total material, expression of cyclin E and of CDC25A were found upregulated in 31.9% and 39.4% of cells, respectively. Both CDC25A and cyclin E protein expression levels were correlated with Ki67 expression level (p<0.001). In addition, the expression of CDC25A was associated significantly with poor survival (P=0.028), whereas no correlation was found with cyclin E. These findings suggest a possible prognostic value for CDC25A as a cell cycle marker and may imply in characteristic of high risk breast cancer patients.
机译：细胞周期控制中的缺陷是癌症的标志性特征。我们研究了Ki67标记指数，细胞周期蛋白E和CDC25A表达与乳腺癌临床随访数据的关系。流式细胞仪用于检测44例浸润性乳腺癌组织中细胞周期蛋白的基因扩增。多元Cox比例风险比检验用于显示相关性。 Cyclin E或CDC25A在34％的肿瘤中上调。在全部材料中，发现细胞周期蛋白E和CDC25A的表达分别在31.9％和39.4％的细胞中上调。 CDC25A和细胞周期蛋白E蛋白表达水平均与Ki67表达水平相关（p <0.001）。此外，CDC25A的表达与不良的存活率显着相关（P = 0.028），而与细胞周期蛋白E则没有相关性。这些发现表明CDC25A作为细胞周期标志物可能具有预后价值，并可能暗示高危特征乳腺癌患者。

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