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首页> 外文期刊>Cell biology international. >Wnt3a is involved in the early stage of miPSC and mESC haemopoietic differentiation
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Wnt3a is involved in the early stage of miPSC and mESC haemopoietic differentiation

机译：Wnt3a参与miPSC和mESC造血分化的早期阶段

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The Wnt/β-catenin signalling pathway is important in regulating not only self-renewal of haemopoietic progenitors and stem cells but also haemopoietic differentiation of ESCs (embryonic stem cells). However, it is still not clear how it affects haemopoietic differentiation. We have used a co-culture system for haemopoietic differentiation of mouse ESCs and iPSCs (induced pluripotent stem cells) in which the Wnt3a gene-modified OP9 cell line is used as stromal cells. The number of both Flk1 + and CD41 + cells generated from both co-cultured mouse ESCs and mouse iPSCs increased significantly, which suggest that Wnt3a is involved in the early stages of haemopoietic differentiation of mouse ESCs and mouse iPSCs in vitro.
机译：Wnt /β-catenin信号通路不仅在调节造血祖细胞和干细胞的自我更新中，而且在调节ESC（胚胎干细胞）的造血分化中都非常重要。但是，尚不清楚它如何影响造血分化。我们已使用共培养系统对小鼠ESC和iPSC（诱导多能干细胞）进行造血分化，其中Wnt3a基因修饰的OP9细胞系用作基质细胞。从共培养的小鼠ESC和小鼠iPSC产生的Flk1 +和CD41 +细胞的数量均显着增加，这表明Wnt3a参与了小鼠ESC和小鼠iPSC的造血分化的早期阶段。

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