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首页> 外文期刊>Cell biology international. >Maternal caffeine exposure impairs insulin secretion by pancreatic beta-cells and increases the risk of type II diabetes mellitus in offspring
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Maternal caffeine exposure impairs insulin secretion by pancreatic beta-cells and increases the risk of type II diabetes mellitus in offspring

机译：孕妇摄入咖啡因会损害胰腺β细胞的胰岛素分泌并增加后代II型糖尿病的风险

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Maternal caffeine exposure may be one of the causes for intrauterine growth retardation and low birth weight (LBW), and increased risk of type 2 diabetes mellitus (T2DM) in the adulthood has been associated with LBW. However, whether maternal caffeine exposure contributes to T2DM development of her offspring has not been fully investigated. We have investigated the influence of maternal caffeine exposure on glucose homeostasis in vivo and effects of long-term caffeine load on insulin secretion of beta-cells. The intake of caffeine during gestation markedly decreases birth weight and postnatal body weight of the offspring. Serum insulin levels of adult offspring after oral glucose tolerance test (OGTT) were significantly lower in the caffeine group compared to the control, although plasma glucose levels were not significantly altered. Proteome analysis of pancreas of adult offspring identified 24 proteins that were differentially expressed between the caffeine and control groups, including proteins involved in energy metabolism. In a rat pancreatic beta-cell line Rin-5f cells, caffeine downregulated expression of one of the proteins involved in insulin synthesis, P4hb, and there was reduced transcriptional expression of insulin. While basal insulin secretion of caffeine-treated cells was elevated, insulin secretion after glucose challenge in long-term caffeine-treated cells was significantly reduced, with increased apoptosis of P-cells. These results indicate that maternal caffeine exposure may result in potentially abnormal glucose homeostasis and increase the risk of T2DM in the offspring adulthood.
机译：孕产妇咖啡因暴露可能是宫内发育迟缓和低出生体重（LBW）的原因之一，并且成年后2型糖尿病（T2DM）的患病风险与LBW有关。但是，母体咖啡因暴露是否有助于其后代的T2DM发育尚未得到充分研究。我们已经调查了孕妇咖啡因暴露对体内葡萄糖稳态的影响以及长期咖啡因负荷对β细胞胰岛素分泌的影响。妊娠期间摄入咖啡因可显着降低后代的出生体重和出生后体重。尽管血浆葡萄糖水平没有明显改变，但咖啡因组的口服葡萄糖耐量试验（OGTT）后的成年后代血清胰岛素水平明显低于对照组。对成年后代胰腺进行的蛋白质组分析确定了24种在咖啡因和对照组之间差异表达的蛋白质，包括参与能量代谢的蛋白质。在大鼠胰腺β细胞系Rin-5f细胞中，咖啡因下调了参与胰岛素合成的一种蛋白质P4hb的表达，并且胰岛素的转录表达降低。虽然咖啡因处理过的细胞的基础胰岛素分泌增加，但长期咖啡因处理过的细胞中葡萄糖激发后的胰岛素分泌却显着减少，P细胞凋亡增加。这些结果表明，孕妇咖啡因暴露可能导致潜在的葡萄糖稳态异常，并增加后代成年后患T2DM的风险。

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