By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells

TsubakiM.; KomaiM.; ItohT.; ImanoM.; SakamotoK.; ShimaokaH.; TakedaT.; OgawaN.; MashimoK.; FujiwaraD.; MukaiJ.; SakaguchiK.; SatouT.; NishidaS.

首页> 外文期刊>Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis >By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells

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By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells

机译：通过抑制Src，维拉帕米和达沙替尼通过在人多药耐药性骨髓瘤细胞中增加Bim表达并降低MDR1和survivin的表达，从而克服了多药耐药性

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The calcium channel blocker verapamil inhibits the transport function of multidrug resistance protein 1 (MDR1). Although verapamil acts to reverse MDR in cancer cells, the underlying mechanism remains unclear. In the present study, we investigated the mechanism of reversing MDR by verapamil in anti-cancer drug-resistant multiple myeloma (MM) cell lines. We found that verapamil suppresses MDR1 and survivin expressions and increases Bim expression via suppression of Src activation. Furthermore, dasatinib reversed the drug-resistance of the drug-resistant cell lines. These findings suggest that Src inhibitors are potentially useful as an anti-MDR agent for the treatment of malignant tumor cells.

机译：钙通道阻滞剂维拉帕米可抑制多药耐药蛋白1（MDR1）的转运功能。尽管维拉帕米可逆转癌细胞中的MDR，但其潜在机制仍不清楚。在本研究中，我们研究了维拉帕米逆转MDR的机制，以抗癌药耐药的多发性骨髓瘤（MM）细胞系。我们发现维拉帕米抑制MDR1和survivin表达，并通过抑制Src激活增加Bim表达。此外，达沙替尼逆转了耐药细胞系的耐药性。这些发现表明，Src抑制剂可能作为抗MDR剂用于治疗恶性肿瘤细胞。

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《Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis》 |2014年第1期|共10页
作者
TsubakiM.; KomaiM.; ItohT.; ImanoM.; SakamotoK.; ShimaokaH.; TakedaT.; OgawaN.; MashimoK.; FujiwaraD.; MukaiJ.; SakaguchiK.; SatouT.; NishidaS.;
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正文语种 eng
中图分类肿瘤学;
关键词
Bim; Dasatinib; Drug resistance; MDR1; Multiple myeloma; Src; Survivin; Verapamil;

机译：Bim;达沙替尼;耐药性;MDR1;多发性骨髓瘤;Src;存活蛋白;维拉帕米;

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1. By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells [J] . TsubakiM., KomaiM., ItohT., Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2014,第1期

机译：通过抑制Src，维拉帕米和达沙替尼通过在人多药耐药性骨髓瘤细胞中增加Bim表达并降低MDR1和survivin的表达，从而克服了多药耐药性
2. By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells [J] . TsubakiM., KomaiM., ItohT., Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2014,第1期

机译：通过抑制SRC，Verapamil和Dasatinib通过增加BIM的表达和MDR1和Survivin的表达增加，克服多药抗性，并且在人类多药中的骨髓瘤细胞中的表达
3. Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells [J] . TsubakiM., SatouT., ItohT., Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2012,第10期

机译：MDR1和survivin的过度表达以及Bim表达的降低介导了多发性骨髓瘤细胞的多药耐药性
4. Inhibiting survivin expression increases the radiosensitivity of human hepatomaHepG2 cells to high-LET carbon ions [C] . X.D. Jin, Q. Li, P. Li, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：抑制survivin表达可增加人类肝癌的放射敏感性HepG2细胞转化为高LET碳离子
5. Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors [D] . Arnst, Kinsie E. 2018

机译：靶向微管蛋白的血清序列结合位点以克服选择性Survivin抑制剂的多药耐药性和抗癌疗效
6. Expression of multidrug resistance-associated protein (MRP) MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines. [O] . S. Hasegawa, T. Abe, S. Naito, 1995

机译：多药耐药性相关蛋白（MRP）MDR1和DNA拓扑异构酶II在人多药耐药性膀胱癌细胞系中的表达。
7. Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines. [O] . Hasegawa, S., Abe, T., Naito, S., 1995

机译：多药耐药性相关蛋白（MRP），MDR1和DNA拓扑异构酶II在人多药耐药性膀胱癌细胞系中的表达。

By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells

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