Quantitative Aspects of RNA Silencing in Metazoans

A. M. Sergeeva; N. Pinzon Restrepo; H. Seitz

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Quantitative Aspects of RNA Silencing in Metazoans

机译：后生动物RNA沉默的定量方面。

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Small regulatory RNAs (microRNAs, siRNAs, and piRNAs) exhibit several unique features that clearly distinguish them from other known gene regulators. Their genomic organization, mode of action, and proposed biological functions raise specific questions. In this review, we focus on the quantitative aspect of small regulatory RNA biology. The original nature of these small RNAs accelerated the development of novel detection techniques and improved statistical methods and promoted new concepts that may unexpectedly generalize to other gene regulators. Quantification of natural phenomena is at the core of scientific practice, and the unique challenges raised by small regulatory RNAs have prompted many creative innovations by the scientific community.

机译：小型调节性RNA（microRNA，siRNA和piRNA）具有几个独特的功能，可以将它们与其他已知的基因调节剂区分开来。它们的基因组组织，作用方式和拟议的生物学功能提出了具体的问题。在这篇综述中，我们关注于小型调节性RNA生物学的定量方面。这些小RNA的原始性质加速了新型检测技术的发展和改进的统计方法，并促进了可能意外地推广到其他基因调节剂的新概念。自然现象的量化是科学实践的核心，而小型监管RNA提出的独特挑战促使科学界进行了许多创造性的创新。

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《Biochemistry》 |2013年第6期|共14页
作者
A. M. Sergeeva; N. Pinzon Restrepo; H. Seitz;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
small RNAs; RNA silencing; RNA interference;

机译：小RNA;RNA沉默;RNA干扰;

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专利

1. Quantitative Aspects of RNA Silencing in Metazoans [J] . A. M. Sergeeva, N. Pinzon Restrepo, H. Seitz Biochemistry . 2013,第6期

机译：后生动物RNA沉默的定量方面。
2. Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors. [J] . Takahashi Y, Yamaoka K, Nishikawa M, Journal of pharmaceutical sciences. . 2009,第1期

机译：从质粒载体表达的小干扰RNA或短发夹RNA诱导的肿瘤细胞中基因沉默的定量和时间分析。
3. Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA [J] . Petr Pancoska, Zdenek Moravek, Ute M. Moll Nucleic Acids Research . 2004,第4期

机译：有效的RNA干扰取决于靶序列的整体情况：使用siRNA的欧拉图表示定量分析沉默效率
4. Quantitative Estimation of siRNAs Gene Silencing Capability by Random Forest Regression Model [C] . Peng Jiang, Xiao Sun, Zuhong Lu The 1st International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2007) . 2007

机译：随机森林回归模型对siRNAs基因沉默能力的定量估计
5. Quantitative RNA Analysis and Roles of Viral RNA Silencing Suppressors in Transient Therapeutic Protein Production in Plant Tissues using a Viral Amplicon-Based System. [D] . Rattanaporn, Kittipong. 2013

机译：定量RNA分析和病毒RNA沉默抑制剂在植物组织中使用基于病毒扩增子的系统中瞬时治疗性蛋白质生产中的作用。
6. Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA [O] . Petr Pancoska, Zdenek Moravek, Ute M. Moll 2004

机译：有效的RNA干扰取决于靶序列的整体情况：使用siRNA的欧拉图表示定量分析沉默效率
7. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation [O] . Otis Pinkard, Sean McFarland, Thomas Sweet, 2020

机译：定量TRNA测序揭示甲基组织特异性TRNA调节

Quantitative Aspects of RNA Silencing in Metazoans

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