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首页> 外文期刊>Cell motility and the cytoskeleton >Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient.
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Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient.

机译：迁移的内皮细胞中的Caveolin-1极化是由底物拓扑而非化学引力梯度指导的。

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摘要

Polarization is a hallmark of migrating cells, and an asymmetric distribution of proteins is essential to the migration process. Caveolin-1 is highly polarized in migrating endothelial cells (EC). Several studies have shown caveolin-1 accumulation in the front of migrating EC while others report its accumulation in the EC rear. In this paper we address these conflicting results on polarized localization of caveolin-1. We find evidence for the hypothesis that different modes of locomotion lead to differences in protein polarization. In particular, we show that caveolin-1 is primarily localized in the rear of cells migrating on a planar substrate, but in the front of cells traversing a three-dimensional pore. We also show that a chemoattractant, present either as a gradient or ubiquitously in the medium, does not alter caveolin-1 localization in cells in either mode of locomotion. Thus we conclude that substrate topology, and not the presence of a chemoattractant, directs the polarization of caveolin-1 in motile ECs.
机译：极化是迁移细胞的标志，蛋白质的不对称分布对于迁移过程至关重要。 Caveolin-1在迁移的内皮细胞（EC）中高度极化。多项研究表明，caveolin-1在迁移的EC的前部富集，而另一些研究则表明其在EC的后部富集。在本文中，我们针对小窝蛋白1的极化定位解决了这些矛盾的结果。我们发现以下假设的证据，即不同的运动模式导致蛋白​​质极化差异。特别是，我们表明小窝蛋白1主要位于在平面基底上迁移的细胞的后部，但位于穿过三维孔的细胞的前部。我们还显示了一种化学引诱剂，无论是作为梯度存在还是在介质中普遍存在，都不会改变任一运动方式下细胞中的Caveolin-1定位。因此，我们得出的结论是，底物拓扑结构而不是化学引诱剂的存在指导了运动型EC中小窝蛋白1的极化。

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