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首页> 外文期刊>Leprosy review >Lymphostimulatory and delayed-type hypersensitivity responses to a candidate leprosy vaccine strain: Mycobacterium habana.
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Lymphostimulatory and delayed-type hypersensitivity responses to a candidate leprosy vaccine strain: Mycobacterium habana.

机译：对候选麻风疫苗株：分枝杆菌的淋巴刺激和迟发型超敏反应。

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Lymphostimulatory and delayed-type hypersensitivity (DTH) immune responses to a candidate antileprosy vaccine Mycobacterium habana have been quantified in inbred AKR mice. M. habana vaccine in three physical states, live, heat-killed and gamma-irradiated, was given intradermally to separate groups of mice and after 28 days these mice were given subcutaneous challenge with heat-killed M. leprae and heat-killed M. habana in the left hind footpad. Live BCG vaccine alone and in combination with gamma-irradiated M. habana were also compared similarly. A sufficient degree of DTH response was generated in mice by M. habana vaccine in all physical forms against two challenge antigens (lepromin and habanin). The BCG combination with M. habana did not increase the DTH response indicating internal adjuvanticity endowed in M. habana. The active hypersensitivity of immunized mice was transferable to syngeneic mice by the transfer of sensitized cells from the donor to the recipient mice intravenously. M. leprae-infected Rhesus monkey PBMC have shown comparable stimulatory response with M. habana (sonicate), and M. leprae (sonicate) antigens. The possibility of developing M. habana as a candidate antileprosy vaccine is discussed.
机译：在近亲AKR小鼠中已经量化了对候选抗麻风病疫苗Habana的淋巴刺激和迟发型超敏反应（DTH）的免疫反应。在三种物理状态下，分别对活的，热灭活的和伽马射线照射的哈巴纳分枝杆菌疫苗进行皮内分离，分别给几组小鼠皮下注射，然后在28天后，对这些小鼠进行皮下攻击，分别使用热灭活的麻风分枝杆菌和热灭活的麻风分枝杆菌。哈瓦那在左后脚掌。还单独比较了单独的活卡介苗和结合伽马射线辐照的哈瓦那分支杆菌的活卡介苗。哈巴纳分枝杆菌疫苗以所有物理形式针对两种攻击抗原（精蛋白和哈巴宁）在小鼠中产生了足够程度的DTH反应。卡介苗与花椰分枝杆菌的结合不会增加DTH反应，表明花椰分枝杆菌具有内部佐剂性。通过将致敏细胞从供体静脉内转移至受体小鼠，可将免疫小鼠的主动超敏反应转移至同系小鼠。麻风分枝杆菌感染的恒河猴PBMC已显示出与哈瓦那分枝杆菌（声波）和麻风分枝杆菌（声波）抗原相当的刺激反应。讨论了将哈巴纳分枝杆菌（M. habana）开发为抗麻风病候选疫苗的可能性。

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