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首页> 外文期刊>Leukemia and lymphoma >Prophylactic low-dose aspirin is effective antithrombotic therapy for combination treatments of thalidomide or lenalidomide in myeloma.
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Prophylactic low-dose aspirin is effective antithrombotic therapy for combination treatments of thalidomide or lenalidomide in myeloma.

机译：预防性小剂量阿司匹林是用于沙利度胺或来那度胺联合治疗骨髓瘤的有效抗血栓形成疗法。

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Multiple myeloma (MM) patients have a propensity for thromboembolic events (TE), and treatment with thalidomide/dexamethasone or lenalidomide/dexamethasone increases this risk. This report describes the use of low-dose aspirin (81 mg) as primary thromboprophylaxis in three series of MM patients receiving thalidomide or lenalidomide with other drugs. In the first regimen (clarithromycin, thalidomide, dexamethasone), initiation of low-dose aspirin negated the occurrence of any further TE. In a second study, prophylactic aspirin given with thalidomide/dexamethasone resulted in a rate of TE similar to that seen with dexamethasone alone (without aspirin). A third study (n = 72) evaluated thrombosis rates with aspirin and a lenalidomide-containing regimen (clarithromycin, lenalidomide, dexamethasone). Of nine occurrences of thromboembolism, five were associated with aspirin interruption or poor compliance. Low-dose aspirin appears to reduce the incidence of thrombosis with these regimens. Routine use of aspirin as antithrombotic prophylaxis in MM patients receiving immunomodulatory drugs with corticosteroids is warranted.
机译：多发性骨髓瘤（MM）患者倾向于发生血栓栓塞事件（TE），而沙利度胺/地塞米松或来那度胺/地塞米松治疗会增加这种风险。该报告描述了在接受沙利度胺或来那度胺与其他药物治疗的三系列MM患者中，低剂量阿司匹林（81毫克）作为主要的血栓预防药物的用途。在第一个方案（克拉霉素，沙利度胺，地塞米松）中，低剂量阿司匹林的启动可消除进一步TE的发生。在第二项研究中，与沙利度胺/地塞米松联合使用的预防性阿司匹林导致的TE发生率与单独使用地塞米松（不使用阿司匹林）所观察到的相似。第三项研究（n = 72）评估了阿司匹林和含来那度胺方案（克拉霉素，来那度胺，地塞米松）的血栓形成率。在9例血栓栓塞事件中，有5例与阿司匹林中断或依从性差有关。小剂量阿司匹林似乎可以减少这些方案的血栓形成发生率。在接受皮质类固醇免疫调节药物治疗的MM患者中，常规使用阿司匹林预防血栓形成是有必要的。

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