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首页> 外文期刊>Cardiovascular therapeutics >Nutraceuticals in cardiovascular prevention: lessons from studies on endothelial function.
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Nutraceuticals in cardiovascular prevention: lessons from studies on endothelial function.

机译：在心血管疾病预防中的营养保健品：来自内皮功能研究的课程。

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An "unhealthy" diet is considered as a main cause of increased atherosclerotic cardiovascular disease in the industrialized countries. There is a substantial interest in the potential cardiovascular protective effects of "nutraceuticals," that is food-derived substances that exert beneficial health effects. The correct understanding of cardiovascular effects of these compounds will have important implications for cardiovascular prevention strategies. Endothelial dysfunction is thought to play an important role in development and progression of atherosclerosis, and the characterization of the endothelial effects of several nutraceuticals may provide important insights into their potential role in cardiovascular prevention. At the same time, the analysis of the endothelial effects of nutraceuticals may also provide valuable insights into mechanisms of why certain nutraceuticals may not be effective in cardiovascular prevention, and it may aid in the identification of food-derived substances that may have detrimental cardiovascular effects. These findings further support the notion that nutraceuticals do need support from large clinical outcome trials with respect to their efficacy and safety profile for cardiovascular prevention, before their widespread use can be recommended. In fact, the term nutraceutical was coined to encourage an extensive and profound research activity in this field, and numerous large-scale clinical outcome trials to examine the effects of nutraceuticals on cardiovascular events have now been performed or are still ongoing. Whereas it is possible that single nutraceuticals may be effective in cardiovascular prevention, this field of research provides also valuable insights into which food components may be particularly important for cardiovascular prevention, to further advice the composition of a particularly healthy diet. The present review summarizes recent studies on the endothelial effects of several nutraceuticals, that have been intensely studied.
机译：在工业化国家中，“不健康”饮食被认为是增加动脉粥样硬化性心血管疾病的主要原因。人们对“保健食品”的潜在心血管保护作用非常感兴趣，“保健食品”是产生有益健康影响的食品来源物质。对这些化合物对心血管作用的正确理解将对心血管预防策略具有重要意义。内皮功能障碍被认为在动脉粥样硬化的发展和进程中起着重要作用，几种营养保健品的内皮作用的特征可能提供重要的见解，以了解它们在心血管疾病预防中的潜在作用。同时，对营养保健品的内皮作用的分析也可能提供有价值的见解，说明某些营养保健品为何可能无法有效预防心血管疾病的机制，并且可能有助于鉴定可能对心血管产生不利影响的食物衍生物质。这些发现进一步支持了这样的观点，即在建议广泛使用之前，营养保健品确实需要大型临床结果试验的支持，以帮助其预防心血管疾病的功效和安全性。实际上，“营养保健品”一词的创建是为了鼓励该领域的广泛而深入的研究活动，并且已经进行或仍在进行许多大型临床结果试验，以检查营养保健品对心血管事件的影响。尽管单一的营养保健品可能对预防心血管疾病有效，但该研究领域还提供了有价值的见解，包括哪些食品成分对预防心血管疾病特别重要，以进一步建议特别健康的饮食组成。本综述总结了最近对几种营养保健品的内皮作用的研究。

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