• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cardiovascular therapeutics >Dose-related effect of aspirin on laboratory-defined platelet aggregation and clinical outcome after coronary stenting.
【24h】

Dose-related effect of aspirin on laboratory-defined platelet aggregation and clinical outcome after coronary stenting.

机译：阿司匹林对冠脉支架置入后实验室定义的血小板聚集和临床结局的剂量相关作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Acetylsalicylic acid (aspirin) is widely used in the secondary prevention of coronary artery disease. There is controversy regarding the prevalence of aspirin resistance in patients with coronary artery disease and the effect of dose on resistance. Our primary aims were to determine the degree of platelet responsiveness to aspirin, and to study the influence of dose on platelet inhibition and clinical outcomes after coronary stenting. METHODS AND RESULTS: We prospectively studied the effect of aspirin on platelet function in 106 stable outpatients 6 months after successful percutaneous coronary angioplasty. Participants were randomized in a double-blind, double-crossover study (80 or 500 mg per day for 6 months). The platelet response to aspirin was determined by 10 micromol/L adenosine-5-diphosphate-induced aggregation with light transmission aggregometry. The clinical outcome was determined by single photon emission computed tomography with Tc-99m, and major adverse cardiac events were recorded (myocardial infarction, death, unstable angina or need for revascularization). In both groups 30.2% of the participants were resistant to aspirin. There was no significant difference between the dose of 80 mg compared to 500 mg aspirin in the incidence of aspirin resistance (P= 0.3). No correlation was found between aspirin resistance and clinical outcome (P= 0.4). Female sex and smoking were strongly associated with aspirin resistance. CONCLUSION: The frequency of aspirin resistance is not dependent on the dose of aspirin. Female sex and smoking were the strongest predictors of aspirin resistance. Aspirin resistance is not a predictor of poor clinical outcome in patients who received double antiplatelet therapy.
机译：背景：乙酰水杨酸（阿司匹林）被广泛用于冠心病的二级预防。冠心病患者中阿司匹林耐药的发生率以及剂量对耐药的影响存在争议。我们的主要目的是确定血小板对阿司匹林的反应程度，并研究剂量对冠状动脉支架置入术后血小板抑制和临床结局的影响。方法和结果：我们成功地研究了阿司匹林对成功经皮冠状动脉成形术后6个月的106名稳定患者的血小板功能的影响。将参与者随机分为双盲，双交叉研究（每天80或500毫克，共6个月）。血小板对阿司匹林的反应是通过10 micromol / L腺苷5-二磷酸腺苷诱导的聚集和光透射聚集法测定的。临床结果由Tc-99m单光子发射计算机断层扫描确定，并记录了严重的不良心脏事件（心肌梗塞，死亡，不稳定的心绞痛或需要血运重建）。在两组中，有30.2％的参与者对阿司匹林耐药。与阿司匹林500毫克相比，阿司匹林80毫克的剂量与阿司匹林耐药的发生率无显着差异（P = 0.3）。阿司匹林耐药性与临床结果之间没有相关性（P = 0.4）。女性和吸烟与阿司匹林抵抗密切相关。结论：阿司匹林耐药的频率与阿司匹林剂量无关。女性和吸烟是阿司匹林抵抗的最强预测因子。在接受双重抗血小板治疗的患者中，阿司匹林抗药性不是不良临床预后的指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号