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首页> 外文期刊>Cardiovascular therapeutics >Serum levels of advanced glycation end products (AGEs) are independent correlates of insulin resistance in nondiabetic subjects
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Serum levels of advanced glycation end products (AGEs) are independent correlates of insulin resistance in nondiabetic subjects

机译：晚期糖基化终末产物（AGEs）的血清水平是非糖尿病受试者胰岛素抵抗的独立相关因素

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Background: Advanced glycation end products (AGEs) evoke oxidative stress generation and inflammatory reactions, thus being involved in vascular complications in diabetes. Since oxidative stress and inflammation impair insulin actions as well, it is conceivable that AGEs may play some role in insulin resistance. However, there is no clinical study to examine the relationship between serum levels of AGEs and insulin resistance. This study investigated whether serum AGE levels were independent correlates of insulin resistance in humans. Methods: Three hundred twenty-two nondiabetic Japanese subjects (216 male and 106 female; mean age 61.5 ± 9.1 years) underwent a complete history and physical examination, determinations of blood chemistries, anthropometric and metabolic variables, including AGEs. Serum AGE levels were examined with an enzyme-linked immunosorbent assay. Results: Mean serum AGE levels were 8.96 ± 2.57 U/mL. In univariate analysis, waist circumference, diastolic blood pressure (BP), mean BP, AGEs, low-density lipoprotein (LDL) cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol (inversely), hemoglobin A1c (GHb), creatinine clearance, uric acid, and high sensitivity C-reactive protein were significantly associated with insulin resistance evaluated by homeostasis model assessment of insulin resistance (HOMA-IR) index. After performing multiple regression analysis, waist circumference (P < 0.001), GHb (P < 0.001), triglycerides (P < 0.001), and AGEs (P < 0.01) still remained significant independently. When age-adjusted HOMA-IR levels stratified by AGE tertiles were compared using ANCOVA, a significant trend was demonstrated in both males and females. Conclusion: The present study demonstrated for the first time that serum AGE levels were one of the independent correlates of HOMA-IR index, thus suggesting that AGEs may play some pathological role in insulin resistance in humans.
机译：背景：晚期糖基化终末产物（AGEs）会引起氧化应激反应和炎症反应，从而参与糖尿病的血管并发症。由于氧化应激和炎症也会损害胰岛素作用，因此可以想象AGEs可能在胰岛素抵抗中发挥某些作用。但是，目前尚无临床研究来检查血清AGEs水平与胰岛素抵抗之间的关系。这项研究调查了血清AGE水平是否是人类胰岛素抵抗的独立相关因素。方法：322名日本非糖尿病受试者（男216例，女106例;平均年龄61.5±9.1岁）经历了完整的病史和体格检查，血液化学测定，人体测量学和代谢变量，包括AGEs。用酶联免疫吸附试验检测血清AGE水平。结果：平均血清AGE水平为8.96±2.57 U / mL。在单变量分析中，腰围，舒张压（BP），平均BP，AGEs，低密度脂蛋白（LDL）胆固醇，甘油三酸酯，高密度脂蛋白（HDL）胆固醇（反之），血红蛋白A1c（GHb），肌酐清除率胰岛素抵抗的稳态模型评估（HOMA-IR）指数评估了尿酸，尿酸和高敏感性C反应蛋白与胰岛素抵抗的相关性。进行多元回归分析后，腰围（P <0.001），GHb（P <0.001），甘油三酸酯（P <0.001）和AGEs（P <0.01）仍然独立。当使用ANCOVA比较按年龄三元组分层的年龄调整后的HOMA-IR水平时，在男性和女性中均显示出明显的趋势。结论：本研究首次证明血清AGE水平是HOMA-IR指数的独立相关因素之一，因此表明AGEs可能在人类胰岛素抵抗中起某些病理作用。

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