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首页> 外文期刊>Cardiovascular therapeutics >Oxidative Stress Impairs Endothelial Function in Nondipper Hypertensive Patients
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Oxidative Stress Impairs Endothelial Function in Nondipper Hypertensive Patients

机译：氧化应激损害非d型高血压患者的内皮功能

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Aims: Essential hypertension, as well as other established cardiovascular risk factors, is associated with endothelial dysfunction. Hypertensive patients with a nondipper circadian pattern have a greater risk of cerebrovascular and cardiovascular complications in comparison with those with a dipper circadian pattern. In this study, we evaluated the association between nondipper pattern and endothelial function in patients with essential hypertension. Methods: We evaluated the forearm blood flow (FBF) response to intraarterial acetylcholine (ACh), an endothelium-dependent vasodilator, and sodium nitroprusside (SNP), an endothelium-independent vasodilator, infusions in 190 hypertensive patients stratified according to dipper and nondipper status. The FBF was measured by strain-gauge plethysmography. Effects of oxidative stress on FBF were evaluated by intraarterial infusion of vitamin C. Ambulatory BP monitorings were obtained by a validated oscillometric device (SpaceLabs 90207 Monitor Inc., Issaquah, WA, USA). Results: Systolic and diastolic blood pressures were higher during daytime and lower during night-time in dipper subjects than in nondippers. The peak percent increase in ACh-stimulated FBF was higher in dippers than in nondippers (473% vs. 228%, P < 0.001). The FBF responses to SNP were similar in dipper and nondipper patients. The FBF response to ACh during coinfusion of vitamin C was higher in nondippers rather than in dipper hypertensives. Conclusions: Present data demonstrate that endothelium-dependent vasodilation is impaired in patients who have nondipper hypertension. The effects of vitamin C on impaired ACh-stimulated vasodilation support the hypothesis that oxidative stress contributes to endothelial dysfunction of nondipper hypertensive patients.
机译：目的：原发性高血压以及其他确定的心血管危险因素与内皮功能障碍有关。与具有北斗昼夜节律型的高血压患者相比，非北斗昼夜节律型的高血压患者发生脑血管和心血管并发症的风险更高。在这项研究中，我们评估了原发性高血压患者非ipper型与血管内皮功能之间的关联。方法：我们评估了对190例根据北斗七星和非北斗七星状态分层的高血压患者的动脉内乙酰胆碱（ACh），内皮依赖性血管舒张剂和硝普钠（SNP）（内皮依赖性血管舒张剂）对前臂血流（FBF）的反应。 。通过应变仪体积描记术测量FBF。通过动脉内注入维生素C来评估氧化应激对FBF的影响。动态血压监测是通过经过验证的示波仪器（美国华盛顿州伊萨夸的SpaceLabs 90207 Monitor Inc.）获得的。结果：北斗七星受试者的收缩压和舒张压白天高于白天，而夜间则更低。北斗星中ACh刺激的FBF的峰值增加百分比高于非北斗星（473％对228％，P <0.001）。北斗七星和非北斗七星患者对SNP的FBF反应相似。与非北斗星相比，非北斗星在维生素C共注入过程中对ACh的FBF反应更高。结论：目前的数据表明非non型高血压患者的内皮依赖性血管舒张功能受损。维生素C对ACh刺激的血管舒张功能受损的影响支持以下假设：氧化应激会导致非d型高血压患者的内皮功能障碍。

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