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首页> 外文期刊>Cell biology international. >RBP-Jkappa binds to and represses transcription of the p53 tumor suppressor gene.
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RBP-Jkappa binds to and represses transcription of the p53 tumor suppressor gene.

机译：RBP-Jkappa结合并抑制p53抑癌基因的转录。

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The tightly regulated expression of p53 contributes to genomic stability and transcription of the p53 gene is induced prior to cells entering S-phase, possibly as a mechanism to insure a rapid p53 response in the event of DNA damage. We have previously described the cloning of an additional 1000bp of upstream p53 sequences that play a role in the regulated expression of p53, and identified that C/EBPbeta-2 participates in inducing p53 gene expression in a cell cycle regulated fashion. This report deals with the transcriptional regulator, RBP-Jkappa, an essential target of the Notch receptor signaling pathway. It binds to the p53 promoter in a cell cycle regulation fashion and also serves to repress p53 gene expression. We conclude from these findings that the coordinate expression of C/EBPbeta-2 and RBP-Jkappa may be linked to p53 transcription during G(0) and as cells move into S-phase. Because defects in the Notch signaling pathway have been implicated in carcinogenesis, aberrant RBP-Jkappa expression and deregulated regulation of the p53 tumor suppressor could be an important step in some forms of cancers.
机译：p53的严格调节表达有助于基因组稳定性，并且在细胞进入S期之前诱导p53基因的转录，这可能是在DNA损伤时确保快速p53反应的机制。先前我们已经描述了在p53调控表达中起作用的上游1000bp上游p53序列的克隆，并确定C / EBPbeta-2以细胞周期调控方式参与诱导p53基因表达。该报告涉及转录调节子RBP-Jkappa，它是Notch受体信号通路的重要靶标。它以细胞周期调节方式与p53启动子结合，还用于抑制p53基因表达。我们从这些发现得出结论，C / EBPbeta-2和RBP-Jkappa的协调表达可能与G（0）期间以及随着细胞进入S期的p53转录有关。由于Notch信号通路中的缺陷已与癌变有关，因此异常的RBP-Jkappa表达和p53抑癌基因的失调调节可能是某些形式癌症的重要一步。

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