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首页> 外文期刊>Cell biology international. >Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes.
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Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes.

机译:人脂肪和骨髓间充质干细胞对T淋巴细胞作用的比较。

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摘要

Mesenchymal stem cells (MSCs) are multipotent cells that can be derived either from the bone marrow (bMSCs) or adipose tissue (aMSCs). We have compared the immune regulatory properties of cells derived from bone marrow and adipose tissue to provide a theoretical basis for the choice of stem cell source for transplantation. The phenotypes of bMSCs and aMSCs are similar, differing only in the expression of CD106. aMSCs proliferate faster than bMSCs, but aMSCs suppressed T-lymphocyte proliferation and activation more poorly than bMSCs. Thus cell origin and abundance are important factors in determining the suitability of MSCs for transplantation. Adipose tissue offers a more promising source of cells for such an application.
机译:间充质干细胞(MSC)是可以从骨髓(bMSCs)或脂肪组织(aMSCs)衍生的多能细胞。我们比较了骨髓和脂肪组织细胞的免疫调节特性,为选择干细胞来源提供理论依据。 bMSC和aMSC的表型相似,仅在CD106的表达上有所不同。 aMSC的增殖比bMSC快,但是aMSC抑制T淋巴细胞增殖和活化的能力比bMSC差。因此,细胞来源和丰度是确定MSCs移植适应性的重要因素。脂肪组织为这种应用提供了更有希望的细胞来源。

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