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首页> 外文期刊>Cell and Tissue Research >Local substitution of GDF-15 improves axonal and sensory recovery after peripheral nerve injury.
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Local substitution of GDF-15 improves axonal and sensory recovery after peripheral nerve injury.

机译：GDF-15的局部替代可改善周围神经损伤后的轴突和感觉恢复。

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摘要

The growth/differentiation factor-15, GDF-15, has been found to be secreted by Schwann cells in the lesioned peripheral nervous system. To investigate whether GDF-15 plays a role in peripheral nerve regeneration, we substituted exogenous GDF-15 into 10-mm sciatic nerve gaps in adult rats and compared functional and morphological regeneration to a vehicle control group. Over a period of 11?weeks, multiple functional assessments, including evaluation of pinch reflexes, the Static Sciatic Index and of electrophysiological parameters, were performed. Regenerated nerves were then morphometrically analyzed for the number and quality of regenerated myelinated axons. Substitution of GDF-15 significantly accelerated sensory recovery while the effects on motor recovery were less strong. Although the number of regenerated myelinated axons was significantly reduced after GDF-15 treatment, the regenerated axons displayed advanced maturation corroborating the results of the functional assessments. Our results suggest that GDF-15 is involved in the complex orchestration of peripheral nerve regeneration after lesion.
机译：已经发现生长/分化因子-15，GDF-15，是由受损的周围神经系统中的雪旺氏细胞分泌的。为了研究GDF-15是否在周围神经再生中起作用，我们将外源GDF-15替换为成年大鼠的10 mm坐骨神经间隙，并将其功能和形态学再生与载体对照组进行了比较。在11周的时间内，进行了多项功能评估，包括评估捏反射，静态坐骨神经指数和电生理参数。然后用形态计量学分析再生神经的再生髓鞘轴突的数量和质量。 GDF-15的替代显着加速了感觉恢复，而对运动恢复的影响则不那么强烈。尽管在GDF-15处理后，再生的髓鞘轴突的数量显着减少，但是再生的轴突显示出成熟的成熟，从而证实了功能评估的结果。我们的结果表明，GDF-15参与了病变后周围神经再生的复杂流程。

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