COLCHICINE-RESISTANCE AND ENHANCEMENT OF P-GLYCOPROTEIN ACTIVITY AFTER CO-CULTIVATION OF DRUG-SENSITIVE CELLS WITH MULTIDRUG RESISTANT VARIANTS

Eliseenkova AV; Kakpakova ES; Abdrjashitov RI; Stavrovskaya AA

首页> 外文期刊>Cell biology international. >COLCHICINE-RESISTANCE AND ENHANCEMENT OF P-GLYCOPROTEIN ACTIVITY AFTER CO-CULTIVATION OF DRUG-SENSITIVE CELLS WITH MULTIDRUG RESISTANT VARIANTS

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COLCHICINE-RESISTANCE AND ENHANCEMENT OF P-GLYCOPROTEIN ACTIVITY AFTER CO-CULTIVATION OF DRUG-SENSITIVE CELLS WITH MULTIDRUG RESISTANT VARIANTS

机译：药物敏感细胞与多药耐药变种共培养后的耐多药耐药性和对P-糖蛋白活性的增强

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The role of cellular interactions in the resistance of Djungurian hamster cells to colchicine (CH) and in the efficiency of P-glycoprotein function was studied. Mixtures of CH-resistant and CH-sensitive cells as well as control unmixed cells were propagated for 3 days and the sensitivity of the cells to CH was measured by colony forming assay. identification of individual subpopulations was possible due to genetic marker (6TG-resistance). The data show that the survival of CH-sensitive cells in CH-supplemented medium increased after cocultivation with CH-resistant counterparts. To measure Pgp activity the fluorescent dye RH123 and FACScan analysis were used. Pgp-mediated RH123 efflux increased after co-cultivation of CH-sensitive and CH-resistant cells.

机译：研究了细胞相互作用在Djungurian仓鼠细胞对秋水仙碱（CH）的抗性和P-糖蛋白功能效率中的作用。 CH抗性和CH敏感性细胞以及对照未混合细胞的混合物繁殖3天，并通过集落形成测定法测量细胞对CH的敏感性。归因于遗传标记（6TG抗性），有可能鉴定单个亚群。数据显示，与CH抗性对应物共同培养后，CH敏感培养基中CH敏感细胞的存活率增加。为了测量Pgp活性，使用了荧光染料RH123和FACScan分析。在CH敏感和CH抵抗细胞共同培养后，Pgp介导的RH123外排增加。

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《Cell biology international.》 |1995年第2期|共7页
作者
Eliseenkova AV; Kakpakova ES; Abdrjashitov RI; Stavrovskaya AA;
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正文语种 eng
中图分类细胞生物学;
关键词
Djungarian hamster; Expression; Phenotype; Selection;

机译：仓鼠;表达;表型;选择;

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1. COLCHICINE-RESISTANCE AND ENHANCEMENT OF P-GLYCOPROTEIN ACTIVITY AFTER CO-CULTIVATION OF DRUG-SENSITIVE CELLS WITH MULTIDRUG RESISTANT VARIANTS [J] . Eliseenkova AV, Kakpakova ES, Abdrjashitov RI, Cell biology international. . 1995,第2期

机译：药物敏感细胞与多药耐药变种共培养后的耐多药耐药性和对P-糖蛋白活性的增强
2. PSC 833 induces apoptosis in drug-sensitive human leukemia cell line and modulates resistance to paclitaxel in its multidrug-resistant variant. [J] . Duraj J, Takacsova X, Sedlak J, Anticancer Research: International Journal of Cancer Research and Treatment . 2000,第6B期

机译：PSC 833诱导了对药物敏感的人类白血病细胞系的凋亡，并在其多药耐药性变体中调节对紫杉醇的耐药性。
3. In vitro anticancer activity of folate-modified docetaxel-loaded PLGA nanoparticles against drug-sensitive and multidrug-resistant cancer cells [J] . Yuri I. Poltavets, Alexander S. Zhirnik, Vasilisa V. Zavarzina, Cancer nanotechnology . 2019,第1期

机译：叶酸修饰多西他赛的PLGA纳米粒子对药物敏感性和多重耐药性癌细胞的体外抗癌活性
4. Controlled Drug Delivery to Drug-Sensitive and Multidrug Resistant Cells: Effects of Pluronic Micelles and Ultrasound [C] . Natalya Rapoport, Alexander Marin, Md. Muniruzzaman, American Chemical Society . 2003

机译：对药物敏感和多药抗性细胞的控制药物递送：Pluronic Micelles和超声波的影响
5. The anti-cancer activities of Paeoniae Radix extracts on human hepatocellular carcinoma cell-line HepG2 and multidrug resistant human hepatocellular carcinoma cell-line R-HepG2 and their action mechanisms. [D] . Li, Lok Yee Mandy. 2004

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6. Leaf Extracts from Dillenia philippinensis Rolfe Exhibit Cytotoxic Activity to both Drug-Sensitive and Multidrug-Resistant Cancer Cells [O] . Rachelle Anne S Dante, Regina Joyce E Ferrer, Sonia D Jacinto 2019

机译：Dillenia philippinensis Rolfe的叶提取物对药敏和多药耐药癌细胞均表现出细胞毒活性
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机译：来自Dillenia Philippinensis rolfe的叶子提取物将细胞毒性活性与药物敏感和多药抗性癌细胞

COLCHICINE-RESISTANCE AND ENHANCEMENT OF P-GLYCOPROTEIN ACTIVITY AFTER CO-CULTIVATION OF DRUG-SENSITIVE CELLS WITH MULTIDRUG RESISTANT VARIANTS

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