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首页> 外文期刊>Cell biology international. >A tentative classification of centrosome abnormalities in cancer.
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A tentative classification of centrosome abnormalities in cancer.

机译：癌症中心体异常的初步分类。

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Centrosome anomalies are detected in virtually all human cancers. They have been implicated in multipolar mitoses, chromosome missegregation, and genomic instability. Despite extensive studies on the type and frequency of centrosome anomalies, a causative relationship between centrosome aberrations and chromosomal instability has been difficult to establish. For example, centrosome amplification can be present without associated chromosomal instability. In addition, not all cells appear to be permissive for centrosome-related mitotic defects suggesting that cellular mechanisms that limit the harmful effects of spindle malformation on genome integrity may exist. This review proposes to classify centrosome abnormalities in tumor cells into three groups based on their relevance to genomic instability: primary centrosome overduplication, transient centrosome accumulation, and permanent centrosome accumulation. Whereas the first two categories are associated with an increased risk of chromosomal missegregation, the latter category may not contribute to the propagation of genomic instability. Therefore, centrosome anomalies should not per se be viewed as a universal cause of chromosomal instability, rather, they need to be assessed in the cellular context in which they occur.
机译：实际上在所有人类癌症中都检测到了中心体异常。它们与多极有丝分裂，染色体错聚和基因组不稳定有关。尽管对中心体异常的类型和频率进行了广泛的研究，但很难建立中心体畸变与染色体不稳定性之间的因果关系。例如，可以存在中心体扩增而没有相关的染色体不稳定。此外，并非所有细胞似乎都允许存在中心体相关的有丝分裂缺陷，这表明可能存在限制纺锤体畸形对基因组完整性的有害影响的细胞机制。这篇综述提议根据肿瘤细胞与基因组不稳定性的相关性将肿瘤细胞中的中心体异常分为三类：原发性中心体过度复制，短暂性中心体积累和永久性中心体积累。尽管前两类与染色体错聚的风险增加有关，但后一类可能不会促进基因组不稳定性的传播。因此，中心体异常本身不应该被认为是染色体不稳定的普遍原因，而是需要在它们发生的细胞环境中进行评估。

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