Local delivery of antibiotics via PMMA (polymethyl-methacrylate) has been widely used in the treatment of chronic osteomyelitis for over 40 years. Unfortunately, PMMA is water insoluble, which seriously limits antibiotic delivery. In addition, the polymerization temperature of PMMA is high, and consequently, only heat-stable antibiotics can be used. Therefore our aim has been to develop an effective antibiotic delivery system, which can be loaded with a wide variety of drugs and deliver the molecules in a predictable manner. Capsules with wall thicknesses of 0.3-0.6 mm from PMMA mixtures containing 40-70 w/w% (weight percent) of sorbitol were prepared and their permeability tested with BPB (Bromophenol Blue). Sorbitol content and wall thickness correlated with the BPB release. SEM (scanning electron microscopy) showed that the canalization of capsules also was well correlated with both sorbitol content and wall thickness. The PMMA-sorbitol-based capsule can potentially be a versatile tool in assuring effective delivery of antibiotics and other substances.
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机译：40多年来，通过PMMA（聚甲基丙烯酸甲酯）局部递送抗生素已广泛用于治疗慢性骨髓炎。不幸的是，PMMA不溶于水，这严重限制了抗生素的递送。另外，PMMA的聚合温度高，因此只能使用热稳定的抗生素。因此，我们的目标是开发一种有效的抗生素输送系统，该系统可以装载多种药物并以可预测的方式输送分子。由含有40-70 w / w％（重量百分比）山梨糖醇的PMMA混合物制备壁厚为0.3-0.6 mm的胶囊，并用BPB（溴酚蓝）测试其渗透性。山梨糖醇含量和壁厚与BPB释放相关。 SEM（扫描电子显微镜）显示，胶囊的导管化与山梨糖醇含量和壁厚也有很好的相关性。基于PMMA-山梨糖醇的胶囊可能会成为确保有效递送抗生素和其他物质的多功能工具。
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