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首页> 外文期刊>Cell biology international. >Long-term muscle-derived cell culture: multipotency and susceptibility to cell death stimuli
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Long-term muscle-derived cell culture: multipotency and susceptibility to cell death stimuli

机译：长期肌肉来源的细胞培养：多能性和对细胞死亡刺激的敏感性

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摘要

Improvement in the yield of adult organism stem cells, and the ability to manage their differentiation and survival potential are the major goals in their application in regenerative medicine and in the adult stem cell research. We have demonstrated that adult rabbit muscle-derived cell lines with an unlimited proliferative potential in vitro can differentiate into myogenic, osteogenic, adipogenic and neurogenic lineages. Studies of cell survival in vitro showed that differentiated cells, except neurogenic ones, are more resistant to apoptosis inducers compared to proliferating cells. Resistance to death signals correlated with the level of protein kinase AKT phosphorylation. Skeletal muscle-derived cell lines can be multipurpose tools in therapy. Enhanced resistance of differentiated cells to certain types of damage shows their potential for long-term survival and maintenance in an organism.
机译：成年生物干细胞产量的提高以及控制其分化和存活潜力的能力是其在再生医学和成年干细胞研究中应用的主要目标。我们已经证明，在体外具有无限增殖潜能的成年兔肌肉衍生的细胞系可以分化为成肌，成骨，成脂和神经系。体外细胞存活研究表明，分化细胞除神经源性细胞外，与增殖细胞相比，对凋亡诱导剂的抵抗力更高。对死亡信号的抗性与蛋白激酶AKT磷酸化水平相关。骨骼肌源性细胞系可以成为治疗中的多用途工具。分化细胞对某些类型损伤的增强抵抗力显示了它们在生物体中长期存活和维持的潜力。

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