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Eosinophils in innate immunity: an evolving story.

机译:固有免疫中的嗜酸性粒细胞:一个不断发展的故事。

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摘要

Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story.
机译:嗜酸性粒细胞是在血液中发现的相对较少的先天免疫白细胞。嗜酸性粒细胞释放其破坏组织的阳离子蛋白的能力决定了其末端效应子的功能,历史上一直被认为是针对特定寄生虫的主要效应子机制,并且同样涉及伴随过敏反应(例如哮喘)的组织损伤。然而,在过去的十年中,嗜酸性粒细胞免疫生物学领域取得了长足的进步,揭示了嗜酸性粒细胞从桥接先天和适应性免疫反应到协调组织重塑事件,也成为许多其他先天免疫方面的关键参与者。在这里,我们回顾了目前已知的嗜酸性粒细胞在先天免疫中的多种功能,并讨论了这个不断发展的故事中的新途径。

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