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首页> 外文期刊>Cell and Tissue Research >Calcium signalling and psychiatric disease: Bipolar disorder and schizophrenia
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Calcium signalling and psychiatric disease: Bipolar disorder and schizophrenia

机译：钙信号和精神病：躁郁症和精神分裂症

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摘要

Neurons have highly developed Ca2+ signalling systems responsible for regulating many neural functions such as the generation of brain rhythms, information processing and the changes in synaptic plasticity that underpins learning and memory. The signalling mechanisms that regulate neuronal excitability are particularly important for processes such as sensory perception, cognition and consciousness. The Ca2+ signalling pathway is a key component of the mechanisms responsible for regulating neuronal excitability, information processing and cognition. Alterations in gene transcription are particularly important as they result in subtle alterations in the neuronal signalling mechanisms that have been implicated in many neural diseases. In particular, dysregulation of the Ca2+ signalling pathway has been implicated in the development of some of the major psychiatric diseases such as bipolar disorder (BPD) and schizophrenia.
机译：神经元具有高度发达的Ca2 +信号传导系统，负责调节许多神经功能，例如脑节律的产生，信息处理以及支撑学习和记忆的突触可塑性的变化。调节神经元兴奋性的信号传导机制对于诸如感官知觉，认知和意识等过程特别重要。 Ca2 +信号通路是负责调节神经元兴奋性，信息处理和认知的机制的关键组成部分。基因转录的改变特别重要，因为它们会导致许多神经疾病中涉及的神经元信号传导机制发生细微变化。特别地，Ca 2+信号传导途径的失调已经牵涉到一些主要的精神疾病例如双相情感障碍（BPD）和精神分裂症的发展中。

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