• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Prion >Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia
【24h】

Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia

机译：阿尔茨海默病，双相障碍和精神分裂症中神经钙信号传导的疑难解理

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neurons have highly developed Ca~(2+) signaling systems responsible for regulating a large number of neural functions such as the control of brain rhythms, information processing and the changes in synaptic plasticity that underpin learning and memory. The tonic excitatory drive, which is activated by the ascending arousal system, is particularly important for processes such as sensory perception, cognition and consciousness. The Ca~(2+) signaling pathway is a key component of this arousal system that regulates the neuronal excitability responsible for controlling the neural brain rhythms required for information processing and cognition. Dysregulation of the Ca~(2+)signaling pathway responsible for many of these neuronal processes has been implicated in the development of some of the major neural diseases in man such as Alzheimer disease, bipolar disorder and schizophrenia. Various treatments, which are known to act by reducing the activity of Ca~(2+) signaling, have proved successful in alleviating the symptoms of some of these neural diseases. ^e>michael.berridge@babraham.ac.uk
机译：神经元具有高度发达的CA〜（2+）信号传导系统，负责调节大量神经功能，例如控制脑力学的控制，信息处理和基于学习和记忆的突触可塑性的变化。由上升唤醒系统激活的滋补兴奋驱动对于感觉感知，认知和意识等过程尤为重要。 CA〜（2+）信号通路是该唤起系统的关键组成部分，该系统调节负责控制信息处理和认知所需的神经脑节律的神经元兴奋。负责这些神经元过程中许多神经元过程的CA〜（2+）信号通路的失调涉及开发人类的一些主要神经疾病，如阿尔茨海默病，双相障碍和精神分裂症。已知通过减少Ca〜（2+）信号传导的活性来作用的各种治疗方法证明了减轻了这些神经疾病中的一些症状。 ^ e> michael.berridge@babraham.ac.uk

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号