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首页> 外文期刊>Cell and Tissue Research >Molecular and cellular changes in skin and muscle during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus) are accompanied by changes in deiodinases expression.
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Molecular and cellular changes in skin and muscle during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus) are accompanied by changes in deiodinases expression.

机译：在大西洋大比目鱼（Hippoglossus hippoglossus）变态期间，皮肤和肌肉的分子和细胞变化伴随着脱碘酶表达的变化。

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Flatfish metamorphosis is the most dramatic post-natal developmental event in teleosts. Thyroid hormones (TH), thyroxine (T4) and 3,3'-5'-triiodothyronine (T3) are the necessary and sufficient factors that induce and regulate flatfish metamorphosis. Most of the cellular and molecular action of TH is directed through the binding of T3 to thyroid nuclear receptors bound to promoters with consequent changes in the expression of target genes. The conversion of T4 to T3 and nuclear availability of T3 depends on the expression and activity of a family of 3 selenocysteine deiodinases that activate T4 into T3 or degrade T4 and T3. We have investigated the role of deiodinases in skin and muscle metamorphic changes in halibut. We show that, both at the whole body level and at the cellular level in muscle and skin of the Atlantic halibut (Hippoglossus hippoglossus) during metamorphosis, the coordination between activating (D2) and deactivating (D3) deiodinases expression is strongly correlated with the developmental TH-driven changes. The expression pattern of D2 and D3 in cells of both skin and muscle indicate that TH are necessary for the maintenance of larval metamorphic development and juvenile cell types in these tissues. No break in symmetry occurs in the expression of deiodinases and in metamorphic developmental changes occurring both in trunk skin and muscle. The findings that two of the major tissues in both larvae and juveniles maintain their symmetry throughout metamorphosis suggest that the asymmetric changes occurring during flatfish metamorphosis are restricted to the eye and head region.
机译：比目鱼变态是硬骨鱼类中最戏剧性的产后发育事件。甲状腺激素（TH），甲状腺素（T4）和3,3'-5'-三碘甲腺氨酸（T3）是诱导和调节比目鱼变态的必要和充分因素。 TH的大多数细胞和分子作用是通过T3与结合于启动子的甲状腺核受体的结合直接进行的，从而改变了靶基因的表达。 T4到T3的转化以及T3的核可利用性取决于3个硒代半胱氨酸脱碘酶家族的表达和活性，该家族将T4激活为T3或降解T4和T3。我们研究了大肠中脱碘酶在皮肤和肌肉变态变化中的作用。我们显示，在变态过程中，在大西洋大比目鱼（Hippoglossus hippoglossus）的全身和肌肉和皮肤细胞水平上，激活（D2）和失活（D3）脱碘酶表达之间的协调与发育密切相关。 TH驱动的变化。 D2和D3在皮肤和肌肉细胞中的表达模式表明TH是维持这些组织中幼虫变态发育和幼稚细胞类型所必需的。脱碘酶的表达以及躯干皮肤和肌肉中发生的变态发育变化均不会发生对称性破坏。幼虫和幼体的两个主要组织在整个变态过程中都保持对称的发现表明，在比目鱼变态过程中发生的不对称变化仅限于眼睛和头部区域。

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