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首页> 外文期刊>Cell biology international. >Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway.
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Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway.

机译：丁酸钠通过PTEN /磷酸肌醇3激酶途径诱导胃癌细胞向肠细胞的分化。

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摘要

NaB (sodium butyrate) inhibits cell proliferation and induces differentiation in a variety of tumour cells. In this study, we aimed to determine whether NaB induced differentiation and regulated the expression of the mucosal factor MUC2 through the PTEN/PI3K (phosphoinositide 3-kinase) pathway. BGC823 cells treated with NaB for 24-72 h showed marked inhibition of cell proliferation and alteration in cellular morphology. NaB treatment markedly increased the expression of PTEN and MUC2, but it decreased the expression of PI3K. These effects were enhanced by intervention with PI3K inhibitors and were reduced by intervention with PTEN siRNA. Hence, we conclude that NaB increased PTEN expression, promoted the expression of MUC2 and induced the differentiation of gastric cancer cells through the PTEN/PI3K signalling pathway.
机译：NaB（丁酸钠）抑制细胞增殖并诱导多种肿瘤细胞分化。在这项研究中，我们旨在确定NaB是否通过PTEN / PI3K（磷酸肌醇3激酶）途径诱导分化并调节粘膜因子MUC2的表达。 NaB处理的BGC823细胞24-72小时显示出对细胞增殖和细胞形态改变的明显抑制。 NaB处理显着增加PTEN和MUC2的表达，但降低PI3K的表达。这些作用通过PI3K抑制剂的干预得以增强，而通过PTEN siRNA的干预得以减弱。因此，我们得出结论，NaB通过PTEN / PI3K信号通路增加PTEN表达，促进MUC2表达并诱导胃癌细胞分化。

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