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首页> 外文期刊>Cell biology international. >4-Methylcatechol-induced cell damage in TM4 Sertoli cells
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4-Methylcatechol-induced cell damage in TM4 Sertoli cells

机译：4-甲基邻苯二酚诱导TM4 Sertoli细胞的细胞损伤

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摘要

4-Methylcatechol (4-MC) is one of the metabolites of quercetin, which is a potential drug for neuroprotection and tumorigenesis inhibition. This study was performed to investigate the cytotoxic effect of 4-MC in mouse TM4 Sertoli cells. TM4 Sertoli cell viability was significantly inhibited by 4-MC in a time- and dose-dependent manner. The number of apoptotic and dead cells was significantly increased after 4-MC treatment. Caspase 3 activity increased by prolonged exposure of TM4 Sertoli cells to 200M 4-MC. The 4-MC significantly upregulated the mRNA level of Bax gene and considerably downregulated the Bcl-2 gene expression in a concentration-dependent manner. Results showed that 4-MC could induce TM4 Sertoli cell apoptosis, and the cytotoxic effect of 4-MC on TM4 Sertoli cells may be associated with upregulated Bax gene expression, which induced caspase cascade activation.
机译：4-甲基邻苯二酚（4-MC）是槲皮素的一种代谢产物，它是一种潜在的神经保护和抑制肿瘤发生的药物。进行这项研究以研究4-MC对小鼠TM4 Sertoli细胞的细胞毒性作用。 4-MC以时间和剂量依赖性方式显着抑制TM4支持细胞的生存能力。 4-MC处理后，凋亡和死亡细胞的数量显着增加。 TM4 Sertoli细胞长时间暴露于200M 4-MC会增加Caspase 3活性。 4-MC以浓度依赖的方式显着上调Bax基因的mRNA水平，并显着下调Bcl-2基因的表达。结果表明4-MC可以诱导TM4 Sertoli细胞凋亡，并且4-MC对TM4 Sertoli细胞的细胞毒性作用可能与上调Bax基因表达有关，从而诱导胱天蛋白酶级联激活。

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