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首页> 外文期刊>Cell and Tissue Research >Bisphenol A exposure at an environmentally relevant dose induces meiotic abnormalities in adult male rats
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Bisphenol A exposure at an environmentally relevant dose induces meiotic abnormalities in adult male rats

机译：与环境有关剂量的双酚A暴露可导致成年雄性大鼠减数分裂异常

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摘要

Whether environmental exposure to bisphenol A (BPA) may induce reproductive disorders is still controversial but certain studies have reported that BPA may cause meiotic abnormalities in C. elegans and female mice. However, little is known about the effect of BPA on meiosis in adult males. To determine whether BPA exposure at an environmentally relevant dose could induce meiotic abnormalities in adult male rats, we exposed 9-week-old male Wistar rats to BPA by gavage at 20 μg/kg body weight (bw)/day for 60 consecutive days. We found that BPA significantly increased the proportion of stage VII seminiferous epithelium and decreased the proportion of stage VIII. Consequently, spermiation was inhibited and spermatogenesis was disrupted. Further investigation revealed that BPA exposure delayed meiosis initiation in the early meiotic stage and induced the accumulation of chromosomal abnormalities and meiotic DNA double-strand breaks (DSBs) in the late meiotic stage. The latter event subsequently activated the phosphatidylinositol 3-kinase-related protein kinase (ATM). Our results suggest that long-term exposure to BPA may lead to continuous meiotic abnormalities and ultimately put mammalian reproductive health at risk.
机译：环境暴露于双酚A（BPA）是否会引起生殖疾病仍存在争议，但某些研究报道BPA可能导致秀丽隐杆线虫和雌性小鼠减数分裂异常。然而，关于双酚A对成年男性减数分裂的作用所知甚少。为了确定在环境相关剂量下暴露于双酚A是否会在成年雄性大鼠中诱发减数分裂异常，我们连续20天以20μg/ kg体重（bw）/天的管饲法将9周大的雄性Wistar大鼠暴露于BPA。我们发现BPA显着增加了VII期生精上皮的比例并降低了VIII期所占的比例。结果，精子被抑制并且精子发生被破坏。进一步的研究表明，BPA暴露在减数分裂初期延迟了减数分裂的启动，并在减数分裂后期诱导了染色体异常的积累和减数分裂DNA双链断裂（DSB）。后者事件随后激活了磷脂酰肌醇3激酶相关的蛋白激酶（ATM）。我们的结果表明，长期接触BPA可能会导致持续的减数分裂异常，并最终使哺乳动物的生殖健康处于危险之中。

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