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首页> 外文期刊>Cell biology international. >Mast cells accumulate in the renal capsule adjacent to transplanted pancreatic islets in rats.
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Mast cells accumulate in the renal capsule adjacent to transplanted pancreatic islets in rats.

机译：肥大细胞在大鼠胰岛附近堆积在肾囊中。

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摘要

Mast cells are important mediators of normal angiogenesis, and participate in normal would healing, i.e. processes involved in pancreatic islet engraftment. The aim of the study was to evaluate if mast cells are present in islet grafts. For this purpose, male normoglycaemic Wistar-Furth rats were either untreated or syngeneically implanted with 250 islets under the renal capsule. The animals were killed 1 month later, and the kidneys and endogenous pancreas were removed, fixed and embedded in paraffin. The distribution of mast cells was studied in Alcian Blue stained sections. Mast cells were rarely encountered in endogenous islets, but were frequent in the renal capsule adjacent to islet grafts. Mast cells interspersed between graft endocrine cells were as rare as in the endogenous pancreas. We conclude that mast cells may contribute to the engraftment after islet transplantation.
机译：肥大细胞是正常血管生成的重要介质，并参与正常的血管愈合，即参与胰岛植入的过程。该研究的目的是评估胰岛移植物中是否存在肥大细胞。为此，不对雄性正常血糖的Wistar-Furth大鼠进行治疗或将其同种植入肾囊下的250个胰岛中。 1个月后将动物杀死，将肾脏和内源性胰腺取出，固定并包埋在石蜡中。在阿尔辛蓝染色切片中研究了肥大细胞的分布。肥大细胞很少在内生的胰岛中遇到，但在胰岛移植物附近的肾囊中很常见。散布在移植内分泌细胞之间的肥大细胞与内源性胰腺一样罕见。我们得出的结论是，胰岛移植后肥大细胞可能有助于移植。

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