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首页> 外文期刊>Cell and Tissue Research >Transplantation of bone-marrow-derived mesenchymal and epidermal stem cells contribute to wound healing with different regenerative features
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Transplantation of bone-marrow-derived mesenchymal and epidermal stem cells contribute to wound healing with different regenerative features

机译：骨髓间充质和表皮干细胞的移植有助于伤口愈合，具有不同的再生特征

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摘要

A new concept for wound therapy is the initiation of the regeneration of epidermal and dermal layers with appendages for skin function recovery. Bone-marrow-derived mesenchymal and epidermal stem cells (BMSCs and SSCs) are hypothesized to be able to home toward or to be transplanted to wound sites for skin repair and regeneration, but this awaits confirmation by further experimental and clinical evidence. In this study, the influence of the transplantation of BMSCs and SSCs with porous gelatin-β-tricalcium phosphate sponge as scaffolds on wound re-epithelization, collagen synthesis, skin tensile strength recovery, and skin appendage regeneration has been investigated. The transplantation of BMSCs or SSCs significantly accelerates wound re-epithelization, stimulates dermal collagen synthesis, and exhibits the trend to enhance the tensile strength recovery of skin. Furthermore, regenerative features of BMSCs and SSCs have been identified in activating blood vessel and hair follicle formation, respectively. These results not only provide experimental evidence for the application of BMSCs and SSCs as promising therapeutics for clinical wound treatment, but also display their characteristics in activating distinct skin appendage regeneration, which might have novel applications in skin tissue engineering.
机译：伤口治疗的新概念是启动表皮和真皮层以及附肢的皮肤功能恢复的再生。假设骨髓来源的间充质和表皮干细胞（BMSCs和SSCs）能够归巢或移植到伤口部位进行皮肤修复和再生，但这尚待进一步的实验和临床证据证实。在这项研究中，已经研究了以多孔明胶-β-磷酸三钙海绵为支架的BMSCs和SSCs移植对伤口再上皮，胶原蛋白合成，皮肤抗张强度恢复和皮肤附件再生的影响。 BMSCs或SSCs的移植显着加速了伤口的再上皮形成，刺激了真皮胶原蛋白的合成，并呈现出增强皮肤抗张强度的趋势。此外，已经分别在激活血管和毛囊形成中鉴定了BMSC和SSC的再生特征。这些结果不仅为将BMSCs和SSCs用作临床伤口治疗的有希望的疗法提供了实验证据，而且还展示了它们在激活独特的皮肤附件再生中的特性，这可能在皮肤组织工程中具有新的应用。

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