Mitosis is not the only distributor of mutated cells: non-mitotic endopolyploid cells produce reproductive genome-reduced cells.

Walen KH

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Mitosis is not the only distributor of mutated cells: non-mitotic endopolyploid cells produce reproductive genome-reduced cells.

机译：有丝分裂不是突变细胞的唯一分配者：非有丝分裂内源多倍体细胞产生生殖基因组减少的细胞。

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Giant endopolyploid nuclei (>16n) can spontaneously fragment by endomitosis (nuclear internal division) into near-diploid cells with reproductive capacity (depolyploidization), and endotetra/octopolyploidy can undergo chromosome-visible meiotic-like genome reductional divisions also to replicative subcells. These unconventional divisions are associated with production of aneuploidy, which led to the question in this study of whether endopolyploidy, in general, can contribute genetic variability to tumorigenic potential. For this purpose, non-proliferative endopolyploid cells (range: 4n-32n) in near-senescence of normal diploid cell strains were analysed for nuclear-morphogenic changes associated with the presence of diploid-sized nuclei in the cytoplasm. A one-by-one nuclear-cutoff process gave rise to reproducing genome-reduced cells. It was concluded that these unconventional cell divisions are, indeed, suspects of originating genetic variability. Details of these irregular mitoses were compared to 'mitotic-meiosis' in primitive organisms, which suggested activation of an ancestral trait in the mammalian cells.

机译：巨大的内倍体核（> 16n）可以通过内吞作用（核内分裂）自发分裂成具有繁殖能力的近二倍体细胞（去多倍体化），而内四倍体/八倍体可以经历染色体可见的减数分裂样基因组还原分裂，也可以复制到复制性亚细胞上。这些非常规的分裂与非整倍性的产生有关，这导致了本研究中的一个问题，即多倍体通常是否可以导致致癌潜力的遗传变异。为此目的，分析了正常二倍体细胞株接近衰老的非增殖性内源多倍体细胞（范围：4n-32n）中与细胞质中二倍体大小的核有关的核形态发生变化。一对一的核切除过程产生了繁殖减少基因组的细胞。结论是，这些非常规的细胞分裂确实是起源遗传变异的怀疑。将这些不规则有丝分裂的细节与原始生物体中的“有丝分裂减数分裂”进行了比较，这提示了哺乳动物细胞中祖先性状的激活。

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《Cell biology international.》 |2010年第8期|共6页
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Walen KH;
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1. Mitosis is not the only distributor of mutated cells: non-mitotic endopolyploid cells produce reproductive genome-reduced cells. [J] . Walen KH Cell biology international. . 2010,第8期

机译：有丝分裂不是突变细胞的唯一分配者：非有丝分裂内源多倍体细胞产生生殖基因组减少的细胞。
2. Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks. [J] . Ivanov A, Cragg MS, Erenpreisa J, Journal of Cell Science . 2003,第Pta20期

机译：严重的基因毒性损伤后产生的内多倍体细胞具有修复DNA双链断裂的潜力。
3. Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells. [J] . Shi X, Wang L, Zhi Y, Virus Research: An International Journal of Molecular and Cellular Virology . 2010,第1期

机译：猪繁殖与呼吸综合征病毒（PRRSV）可以通过专业的β干扰素产生系统来感知，并具有在MARC-145细胞中抑制该作用的机制。
4. Wavelet-based statistical features for distinguishing mitotic and non-mitotic cells in breast cancer histopathology [C] . Tao Wan, Xu Liu, Jianhui Chen, IEEE International Conference on Image Processing . 2014

机译：基于小波的统计特征可区分乳腺癌组织病理学中的有丝分裂和非有丝分裂细胞
5. The Cellular Response to DNA Double Strand Break Damage During Mitosis in Human Cells. [D] . Stephens, Jared Paul. 2011

机译：人类细胞在有丝分裂过程中对DNA双链断裂损伤的细胞反应。
6. Metabolic inhibition of plaque-forming cells: comparison of human rheumatoid-factor-producing cells with mouse anti-sheep erythrocyte-producing cells. [O] . T L Moore, J E Rose, J H Vaughan 1979

机译：噬菌斑形成细胞的代谢抑制：人类类风湿因子产生细胞与小鼠抗绵羊红细胞产生细胞的比较。
7. STUDIES ON THE ORIGIN OF BACTERIAL VIRUSES : I. THE INCIDENCE OF PHAGE-PRODUCING CELLS IN VARIOUS B. MEGATHERIUM CULTURES. II. THE EFFECT OF ULTRAVIOLET LIGHT ON THE INCIDENCE OF PHAGE-PRODUCING CELLS AND OF TERRAMYCIN-RESISTANT CELLS. III. THE EFFECT OF HYDROGEN PEROXIDE ON THE INCIDENCE OF PHAGE-PRODUCING CELLS AND OF TERRAMYCIN-RESISTANT CELLS. IV. CALCULATION OF THE INCIDENCE OF PHAGE-PRODUCING CELLS [O] . Northrop, John H. 1958

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8. Elucidate the Mechanism of Telomere Maintenance in STAG2 Mutated Tumor Cells. [R] . Daniloski, Z. 2017

机译：阐明sTaG2突变肿瘤细胞中端粒维持的机制。

Mitosis is not the only distributor of mutated cells: non-mitotic endopolyploid cells produce reproductive genome-reduced cells.

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