• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition
【24h】

Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition

机译：柚皮苷改变胆固醇喂养条件下LDL受体敲除小鼠的胆固醇生物合成和抗氧化酶活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of the current study was to evaluate the lipid lowering and antioxidant capacity of naringin in LDL receptor knockout (LDLR-KO) mice fed a cholesterol (0.1 g/100 g) diet. As such, naringin or lovastatin (0.02 g/100 g) was supplemented in a cholesterol diet for 6 weeks. The naringin and lovastatin supplementation significantly lowered the plasma total cholesterol level compared to the control group. The plasma and hepatic triglyceride level was only lowered by the lovastatin supplement, while the hepatic cholesterol content was lowered by both the naringin and lovastatin supplements compared to the control group. The hepatic HMG-CoA reductase activity was significantly lower in the naringin and lovastatin supplemented groups than in the control group, whereas the ACAT activity was unaffected. The excretion of total sterol was significantly higher in the naringin and lovastatin groups compared to the control group due to significant changes in the acidic and neutral sterol, respectively. When comparing the hepatic antioxidant enzyme activities, the superoxide dismutase, catalase, and glutathione reductase activities were all significantly higher in the naringin-supplemented group than in the control group, while only the lovastatin supplement increased the glutathione reductase activity. Accordingly, the current results confirmed that naringin lowers the plasma cholesterol level via the inhibition of hepatic HMG-CoA reductase activity and increases the excretion of fecal sterol. Naringin was also found to improve the activities of hepatic antioxidant enzymes against oxidative stress in a hypercholesterolemic animal model, i.e. cholesterol-fed LDLR-KO mice. (C) 2003 Elsevier Inc. All rights reserved. [References: 54]
机译：本研究的目的是评估喂养胆固醇（0.1 g / 100 g）的LDL受体敲除（LDLR-KO）小鼠中柚皮苷的降脂和抗氧化能力。因此，在胆固醇饮食中补充了柚皮苷或洛伐他汀（0.02 g / 100 g）6周。与对照组相比，柚皮苷和洛伐他汀的补充显着降低了血浆总胆固醇水平。与对照组相比，洛伐他汀补充剂仅可降低血浆和肝甘油三酯水平，而柚皮苷和洛伐他汀补充剂均可降低肝胆固醇含量。补充柚皮苷和洛伐他汀的组的肝HMG-CoA还原酶活性明显低于对照组，而ACAT活性未受影响。柚皮苷和洛伐他汀组的总固醇排泄量显着高于对照组，这是由于酸性固醇和中性固醇分别发生了显着变化。比较肝抗氧化酶活性时，补充柚皮苷的组中的超氧化物歧化酶，过氧化氢酶和谷胱甘肽还原酶的活性均显着高于对照组，而只有洛伐他汀补充剂可增加谷胱甘肽还原酶的活性。因此，当前结果证实柚皮苷通过抑制肝HMG-CoA还原酶活性降低血浆胆固醇水平，并增加粪便固醇的排泄。在高胆固醇血症动物模型，即胆固醇喂养的LDLR-KO小鼠中，还发现柚皮苷改善了肝抗氧化酶抵抗氧化应激的活性。 （C）2003 Elsevier Inc.保留所有权利。 [参考：54]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号