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首页> 外文期刊>Life sciences >Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content.
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Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content.

机译：大强度运动训练和合成代谢雄激素治疗对大鼠组织糖原含量的影响。

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To increase tissue glycogen content many athletes use anabolic androgenic steroids (AAS). However, the literature concerning the effects of androgens on glycogen metabolism is conflicting. This study aimed to determine the influence of training and AAS on body weight (bw), triglycerides, glucose, tissue glycogen and transaminases levels. Male Wistar rats, randomized into four groups (sedentary vehicle (SV), sedentary AAS (SA), trained vehicle (TV) and trained AAS (TA)), were treated with nadrolone (5 mg/Kg, 2x/week, i.m.) or vehicle. Trained rats performed jumps into water (4 sets, 10 repetitions, 30 sec rest) carrying a 50-70% body wt-load strapped to the chest (5 days/week,6 weeks). Two days after the last session, the animals were killed (bifatorial ANOVA+Tukey test; P < 0.05). Trained animals presented lower bw (TV:345+/-7 vs. SV:380+/-7 and TA:328+/-4 vs SA:370+/-11 g) and triglycerides levels (TV:77+/-3 vs. SV:98+/-4 and TA:79+/-3 vs. SA:98+/-8 mg/dL) and higher glycogen content in liver (TV:5.3+/-0.2 vs. SV:3.9+/-0.1 and TA:5.3+/-0.3 vs. SA:4.6+/-0,2 mg/100 mg) and in gastrocnemious (TV:0.70+/-0.02 vs. SV:0.49+/-0.01 and TA:0.73+/-0.03 vs. SA:0.57+/-0.02 mg/100 mg) than sedentary ones. In the cardiac muscle, the association between training and AAS increased glycogen content (TA:0.19+/-0.01 > SV:0.13+/-0.01=TV:0.13+/-0.01=SA:0.14+/-0.01 mg/100 mg). In the soleus AAS increased glycogen (SA:0.53+/-0.03 vs. SV:0.43+/-0.01 and TA:0.58+/-0.02 vs. TV:0.48+/-0.01 mg/100 mg). Exercise training and AAS had no effect on blood glucose and transaminases levels. Training and AAS effects on glycogen supercompensation are tissue-dependent and the effects of association between them were only observed in the cardiac muscle. These data emphasize the necessity of more studies to confirm greater effects of AAS than those promoted by physical exercise.
机译：为了增加组织糖原含量，许多运动员使用合成代谢雄激素类固醇（AAS）。但是，有关雄激素对糖原代谢的影响的文献相互矛盾。这项研究旨在确定训练和AAS对体重（bw），甘油三酸酯，葡萄糖，组织糖原和转氨酶水平的影响。将雄性Wistar大鼠随机分为四组（中枢媒介物（SV），久坐AAS（SA），训练有素的媒介物（TV）和训练有素的AAS（TA）），并用萘德隆（5 mg / Kg，2x / week，im）或车辆。受过训练的大鼠跳入水中（4组，重复10次，休息30秒），并带有50-70％的身体重量负荷（5天/周，6周）。最后一次训练后两天，将动物处死（双向ANOVA + Tukey试验; P ＜0.05）。受过训练的动物的bw（TV：345 +/- 7 vs.SV:380+/-7和TA：328 +/- 4 vs SA：370 +/- 11 g）和甘油三酸酯水平较低（TV：77 +/- 3 vs. SV：98 +/- 4和TA：79 +/- 3 vs. SA：98 +/- 8 mg / dL）和肝脏中更高的糖原含量（TV：5.3 +/- 0.2 vs.SV:3.9 +/- 0.1和TA：5.3 +/- 0.3相对于SA：4.6 +/- 0.2 mg / 100 mg）和肠胃营养不良（TV：0.70 +/- 0.02相对于SV：0.49 +/- 0.01和TA ：相对于久坐者为0.73 +/- 0.03，而SA为：0.57 +/- 0.02 mg / 100 mg。在心肌中，训练与AAS之间的关联增加了糖原含量（TA：0.19 +/- 0.01> SV：0.13 +/- 0.01 = TV：0.13 +/- 0.01 = SA：0.14 +/- 0.01 mg / 100 mg ）。比目鱼肌中AAS的糖原增加（SA：0.53 +/- 0.03 vs.SV:0.43+/-0.01和TA：0.58 +/- 0.02 vs.TV:0.48+/-0.01 mg / 100 mg）。运动训练和AAS对血糖和转氨酶水平没有影响。训练和AAS对糖原超补偿的影响是组织依赖性的，并且它们之间的关联影响仅在心肌中观察到。这些数据强调有必要进行更多的研究以证实AAS的效果要优于体育锻炼。

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